The Association Between Dietary Intake of Fats and Transient Global Amnesia (Tga) Publisher Pubmed

Summary: Study finds omega-3 fats may lower risk of transient global amnesia, while omega-6 fats may increase it, impacting memory health. #BrainHealth #Nutrition

Mahmoudi Z¹ ; Tajik A² ; Vahdat M³ ; Mobarakeh KA⁴ ; Saeedirad Z⁵ ; Azaryan F⁶ ; Amjadi A⁷ ; Alami F⁸ ; Valisoltani N⁹ ; Mirshafaei MA¹⁰ ; Khoshdooz S¹¹ ; Gholamalizadeh M¹² ; Doaei S¹³ ; Kooshki A¹⁴
Source: Nutritional Neuroscience Published:2025

Abstract

Background: Different types of dietary fat may influence memory and cognitive functions. This study aimed to investigate the association between dietary fat intake and transient global amnesia (TGA). Methods: This case–control study was conducted using Persian Sabzevar cohort data on 258 individuals with TGA and 520 individuals without amnesia in Sabzevar Iran. The food frequency questionnaire (FFQ) was used to assess the intake of dietary fats of the participants. All study participants were screened for TGA by a neurologist and their status was determined based on the diagnostic symptoms defined by the Kaplan and Hodges criteria. Results: There was an inverse association between the risk of TGA and dietary intake of alpha-linolenic acid (ALA) (OR = 0.94, CI95%:0.88-0.99, P = 0.01). Also, a positive association was observed between TGA and dietary intake of n-6 fatty acids (OR = 1.18, CI 95%: 1.04-1.33, P = 0.01). The results remained significant after adjustment for age, sex, education, job, marital status, physical activity, BMI, and calorie intake. Conclusion: Omega-3 fatty acids may have beneficial effects; however, omega-6 fatty acids may have adverse effects on the risk of amnesia. Further longitudinal studies are warranted. © 2024 Informa UK Limited, trading as Taylor & Francis Group.