Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Effects of Long-Term Phenytoin or Phenytoin Plus Ascorbic Acid Administration on Urethane Anesthetic Effect in Rats: A Controlled Study Publisher



Ghazvini MRA1 ; Ghafghazi T2 ; Hajhashemi V2 ; Ani M3
Authors

Source: Current Therapeutic Research - Clinical and Experimental Published:2002


Abstract

Background: Phenytoin, a widely used anticonvulsant, interacts with many drugs. These interactions may be clinically significant. Objective: This controlled, 31-day study investigated the possible interactions of phenytoin with urethane and ascorbic acid. Methods: Groups of male rats were subjected to long-term oral phenytoin treatment with or without ascorbic acid coadministration. The responsiveness of treated animals to the anesthetic activity of urethane then was investigated by assessing their righting reflexes. Results: Long-term phenytoin treatment resulted in hyporesponsiveness to the urethane anesthetic effect, and this interaction was augmented by ascorbic acid coadministration. Conclusion: Our results indicate that phenytoin interacts with ascorbic acid and urethane in vivo, which may be of clinical and/or experimental importance.