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Optimal Scheduling of the Nanoparticle-Mediated Cancer Photo-Thermo-Radiotherapy Publisher Pubmed

Summary: A study found combining nanoparticle heat therapy with radiation kills more cancer cells, improving treatment. #CancerResearch #Nanotechnology

Safari A1 ; Sarikhani A2 ; Shahbazigahrouei D1 ; Alamzadeh Z2 ; Beik J2 ; Dezfuli AS2 ; Mahabadi VP3, 4 ; Tohfeh M2 ; Shakerizadeh A2, 5
Authors

Source: Photodiagnosis and Photodynamic Therapy Published:2020


Abstract

Maximal synergistic effect between photothermal therapy and radiotherapy (RT) may be achieved when the interval between these two modalities is optimal. In this study, we tried to determine the optimal schedule of the combined regime of RT and nano-photothermal therapy (NPTT), based on the cell cycle distribution and kinetics of cell death. To this end, alginate-coated iron oxide-gold core-shell nanoparticles (Fe3O4@Au/Alg NPs) were synthesized, characterized, and their photo-radio sensitization potency was evaluated on human nasopharyngeal cancer KB cells. Our results demonstrated that synthesized NPs have a good potential in radiotherapy and near-infrared (NIR) photothermal therapy. However, results from flow cytometry analysis indicated that a major portion of KB cells were accumulated in the most radiosensitive phases of cell cycle (G2/M) 24 h after NPTT. Moreover, the maximal synergistic anticancer efficacy (12.3% cell viability) was observed when RT was applied 24 h following the administration of NPTT (NPs [30 μg/mL, 4 h incubation time] + Laser [808 nm, 1 W/cm2, 5 min] + RT [6 Gy]). It is noteworthy that apoptosis was the dominant cell death pathway in the group of cells treated by combination of NPTT and RT. This highly synergistic anticancer efficacy provides a mechanistic basis for Fe3O4@Au/Alg NPs-mediated photothermal therapy combined with RT. Knowing such a basis is helpful to promote novel nanotechnology cancer treatment strategies. © 2020 Elsevier B.V.
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