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Preventive Effect of Exercise on Lipid Peroxidation and Histopathological Changes in Isoproterenol-Induced Myocardial Infarction in Male Rats



Afshin S1 ; Mohammadi M1 ; Soleimani J1 ; Rashidi B2 ; Mohhaddes G1
Authors

Source: Pharmaceutical Sciences Published:2010

Abstract

Objectives: The cardiotoxic effects of isoproterenol (ISO) are associated with, and possibly due to, lipid peroxidation in heart tissue. In this study, the effect of exercise against lipid peroxidation and injuries due to isoproterenol was investigated in rat heart. Methods: 50 Wistar rats were divided into 5 groups: control rats (C), saline (S), Exercise (E), ISO injected (150 mg/kg) (ISO), Exercise + ISO (E+ISO), at the end of the experiment all animals anesthetized and heart tissue were collected for biochemical and histological examinations. Results: Exercise increased GSH (Glutathione), GSSG (Oxidized Glutathione) and decreased TBARS (Thiobarbituric Acid Reactive Substances) levels in ISO group (p<0.05). Also, exercise reduced the rate of edema, inflammatory cells infiltration and degree of necrosis compared with control group. Conclusion: Our results show exercise by reduction of lipid peroxidation and intensity of myocardial injuries may have beneficial protective effects against injuries due to isoproterenol.
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