Design and Synthesis of Novel Cytotoxic Indole-Thiosemicarbazone Derivatives: Biological Evaluation and Docking Study

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Design and Synthesis of Novel Cytotoxic Indole-Thiosemicarbazone Derivatives: Biological Evaluation and Docking Study Publisher Pubmed

Summary: A study found a new compound fights lung and liver cancer cells effectively, surpassing standard drugs. #CancerResearch #NewTreatments

Bakherad Z¹ ; Safavi M² ; Fassihi A¹ ; Sadeghialiabadi H¹ ; Bakherad M³ ; Rastegar H⁴ ; Saeedi M^{5, 6} ; Ghasemi JB⁷ ; Saghaie L¹ ; Mahdavi M⁸

Source: Chemistry and Biodiversity Published:2019

Abstract

In this work, two novel series of indole-thiosemicarbazone derivatives were designed, synthesized, and evaluated for their cytotoxic activity against MCF-7, A-549, and Hep-G2 cell lines in comparison to etoposide and colchicine as the reference drugs. Generally, the synthesized compounds showed better cytotoxicity towards A-549 and Hep-G2 than MCF-7. Among them, (2E)-2-{[2-(4-chlorophenyl)-1H-indol-3-yl]methylidene}-N-(4-methoxyphenyl)hydrazinecarbothioamide (8l) was found to be the most potent compound against A-549 and Hep-G2, at least three times more potent than etoposide. The morphological analysis by the acridine orange/ethidium bromide double staining test and flow cytometry analysis indicated that compound 8l induced apoptosis in A-549 cells. Moreover, molecular docking methodology was exploited to elucidate the details of molecular interactions of the studied compounds with putative targets. © 2019 Wiley-VHCA AG, Zurich, Switzerland

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Style	Citing Format
MLA	Bakherad Z, et al.. "Design and Synthesis of Novel Cytotoxic Indole-Thiosemicarbazone Derivatives: Biological Evaluation and Docking Study." Chemistry and Biodiversity, vol. 16, no. 4, 2019, pp. -.
APA	Bakherad Z, Safavi M, Fassihi A, Sadeghialiabadi H, Bakherad M, Rastegar H, Saeedi M, Ghasemi JB, Saghaie L, Mahdavi M (2019). Design and Synthesis of Novel Cytotoxic Indole-Thiosemicarbazone Derivatives: Biological Evaluation and Docking Study. Chemistry and Biodiversity, 16(4), -.
Chicago	Bakherad Z, Safavi M, Fassihi A, Sadeghialiabadi H, Bakherad M, Rastegar H, Saeedi M, Ghasemi JB, Saghaie L, Mahdavi M. "Design and Synthesis of Novel Cytotoxic Indole-Thiosemicarbazone Derivatives: Biological Evaluation and Docking Study." Chemistry and Biodiversity 16, no. 4 (2019): -.
Harvard	Bakherad Z et al. (2019) 'Design and Synthesis of Novel Cytotoxic Indole-Thiosemicarbazone Derivatives: Biological Evaluation and Docking Study', Chemistry and Biodiversity, 16(4), pp. -.
Vancouver	Bakherad Z, Safavi M, Fassihi A, Sadeghialiabadi H, Bakherad M, Rastegar H, et al.. Design and Synthesis of Novel Cytotoxic Indole-Thiosemicarbazone Derivatives: Biological Evaluation and Docking Study. Chemistry and Biodiversity. 2019;16(4):-.
BibTex	@article{ author = {Bakherad Z and Safavi M and Fassihi A and Sadeghialiabadi H and Bakherad M and Rastegar H and Saeedi M and Ghasemi JB and Saghaie L and Mahdavi M}, title = {Design and Synthesis of Novel Cytotoxic Indole-Thiosemicarbazone Derivatives: Biological Evaluation and Docking Study}, journal = {Chemistry and Biodiversity}, volume = {16}, number = {4}, pages = {-}, year = {2019} }
RIS	TY - JOUR AU - Bakherad Z AU - Safavi M AU - Fassihi A AU - Sadeghialiabadi H AU - Bakherad M AU - Rastegar H AU - Saeedi M AU - Ghasemi JB AU - Saghaie L AU - Mahdavi M TI - Design and Synthesis of Novel Cytotoxic Indole-Thiosemicarbazone Derivatives: Biological Evaluation and Docking Study JO - Chemistry and Biodiversity VL - 16 IS - 4 SP - EP - PY - 2019 ER -

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