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Pegylated Multifunctional Ph-Responsive Targeted Polymeric Micelles for Ovarian Cancer Therapy: Synthesis, Characterization and Pharmacokinetic Study Publisher

Summary: A study found targeted micelles improve cancer drug delivery, enhancing treatment effectiveness. #CancerResearch #DrugDelivery

Kazemi M1 ; Emami J1 ; Hasanzadeh F2 ; Minaiyan M3 ; Mirian M4 ; Lavasanifar A5
Authors

Source: International Journal of Polymeric Materials and Polymeric Biomaterials Published:2021


Abstract

DTX-loaded folate targeted micelles (DTX/FA-PEG-HEP-CA-TOC) were prepared using a dialysis method and the impact of various processing variables were evaluated on micelle properties. In vitro cytotoxicity and in vivo pharmacokinetics of the optimized formulation were evaluated. DTX/FA-PEG-HEP-CA-TOC exhibited average particle size of 90–185 nm with high entrapment efficiency (53–93%) and pH-dependent drug release behavior. DTX/FA-PEG-HEP-CA-TOC micelles exhibited higher toxicity against SKOV3 cells than DTX/HEP-CA-TOC micelles and free DTX. Significant increase in the T 1/2 β, AUC and MRT and decrease in Vd as well as CL values was observed in DTX/FA-PEG-HEP-CA-TOC micelle treated group compared to free DTX treated group. © 2020 Taylor & Francis Group, LLC.
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