Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways That Link Inflammation and Complex Disorders

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways That Link Inflammation and Complex Disorders Publisher Pubmed

Ligthart S¹ ; Vaez A^{2, 3} ; Vosa U^{4, 5} ; Stathopoulou MG⁶ ; De Vries PS^{1, 7} ; Prins BP⁸ ; Van Der Most PJ² ; Tanaka T⁹ ; Naderi E^{2, 10} ; Rose LM¹¹ ; Wu Y¹² ; Karlsson R¹³ ; Barbalic M¹⁴ ; Lin H¹⁵ Show All Authors

Ligthart S¹
Vaez A^{2, 3}
Vosa U^{4, 5}
Stathopoulou MG⁶
De Vries PS^{1, 7}
Prins BP⁸
Van Der Most PJ²
Tanaka T⁹
Naderi E^{2, 10}
Rose LM¹¹
Wu Y¹²
Karlsson R¹³
Barbalic M¹⁴
Lin H¹⁵
Pool R^{16, 17}
Zhu G¹⁸
Mace A^{19, 20, 21}
Sidore C²²
Trompet S^{23, 24}
Mangino M^{25, 26}
Sabaterlleal M^{27, 28}
Kemp JP^{29, 30}
Abbasi A^{2, 31, 32}
Kacprowski T^{33, 34}
Verweij N³⁵
Smith AV^{36, 37}
Huang T^{38, 39}
Marzi C^{40, 41}
Feitosa MF⁴²
Lohman KK⁴³
Kleber ME⁴⁴
Milaneschi Y⁴⁵
Mueller C^{46, 47, 48}
Huq M²
Vlachopoulou E⁴⁹
Lyytikainen LP^{50, 51}
Oldmeadow C^{52, 53}
Deelen J^{54, 55}
Perola M⁵⁶
Zhao JH⁵⁷
Feenstra B⁵⁸
Alizadeh BZ²
Franke L⁴
Snieder H²
Amini M²
Chasman DI^{11, 178}
Ahluwalia TS^{97, 98}
Tracy RP²²⁴
Bis JC²²⁰
Eiriksdottir G³⁶
Gross M²²⁷
Dupuis J^{229, 230}
Koenig W^{171, 214, 215}
Abbasi A^{2, 31, 32}
Nolte IM²
Daveysmith G³⁰
Morrison AC⁷
Boerwinkle E^{225, 226}
Morris AP^{75, 219}
Lahti J^{59, 60, 61}
Schraut KE⁶²
Fornage M⁶³
Suktitipat B⁶⁴
Chen WM⁶⁵
Li X⁶⁶
Nutile T⁶⁷
Malerba G⁶⁸
Luan J⁵⁷
Bak T⁶⁹
Schork N^{70, 71}
Del Greco M F⁷²
Thiering E^{73, 74}
Mahajan A⁷⁵
Marioni RE^{76, 77}
Mihailov E⁵
Ozel AB⁷⁹
Zhang W^{80, 81}
Nethander M⁸²
Cheng YC⁸³
Aslibekyan S⁸⁴
Ang W⁸⁵
Gandin I⁸⁶
Yengo L^{87, 88}
Portas L⁸⁹
Kooperberg C⁹⁰
Hofer E^{91, 92}
Rajan KB⁹³
Schurmann C^{94, 95}
Den Hollander W⁹⁶
Zhao J⁹⁹
Draisma HHM^{16, 17, 100}
Ford I¹⁰¹
Timpson N³⁰
Teumer A¹⁰²
Huang H¹⁰³
Wahl S^{40, 41}
Liu Y⁴³
Huang J¹⁰⁴
Uh HW¹⁰⁵
Geller F⁵⁸
Joshi PK⁶²
Yanek LR¹⁰⁶
Trabetti E⁶⁸
Lehne B⁸⁰
Vozzi D¹⁰⁷
Verbanck M⁸⁷
Biino G¹⁰⁸
Saba Y¹⁰⁹
Meulenbelt I⁹⁶
Oconnell JR⁸³
Laakso M¹¹⁰
Giulianini F¹¹
Magnusson PKE¹³
Ballantyne CM^{111, 112}
Hottenga JJ¹⁶
Montgomery GW¹⁸
Rivadineira F¹¹³
Rueedi R^{19, 20}
Steri M²²
Herzig KH^{114, 115, 116}
Stott DJ¹¹⁷
Menni C²⁵
Franberg M^{28, 118}
St Pourcain B^{30, 119}
Felix SB^{34, 120}
Pers TH^{58, 98}
Bakker SJL³¹
Kraft P¹⁰³
Peters A¹²¹
Vaidya D¹⁰⁶
Delgado G⁴⁴
Smit JH⁴⁵
Gromann V¹²²
Sinisalo J¹²³
Seppala I^{50, 51}
Williams SR¹²⁴
Holliday EG^{52, 53}
Moed M⁵⁴
Langenberg C⁵⁷
Raikkonen K⁶⁰
Ding J¹²⁵
Campbell H⁶²
Sale MM⁶⁵
Chen YDI⁶⁶
James AL^{126, 127}
Ruggiero D^{67, 128}
Soranzo N¹²⁹
Hartman CA⁶⁹
Smith EN¹³⁰
Berenson GS¹³¹
Fuchsberger C^{72, 132}
Tiesler CMT^{73, 74}
Giedraitis V¹³³
Liewald D⁷⁶
Fischer K⁵
Mellstrom D⁷⁸
Larsson A¹³⁴
Wang Y¹³⁵
Scott WR⁸⁰
Lorentzon M^{78, 136}
Beilby J^{137, 138}
Ryan KA⁸³
Pennell CE⁸⁵
Vuckovic D¹³⁹
Balkau B¹⁴⁰
Concas MP¹⁰⁷
Schmidt R⁹¹
Mendes De Leon CF¹⁴¹
Bottinger EP^{94, 142}
Kloppenburg M^{143, 144}
Paternoster L³⁰
Boehnke M¹⁴⁵
Musk AW^{126, 146}
Willemsen G¹⁶
Evans DM^{29, 30}
Madden PAF¹⁴⁷
Kahonen M^{148, 149}
Kutalik Z^{20, 21}
Zoledziewska M²²
Karhunen V¹⁵⁰
Kritchevsky SB¹⁵¹
Sattar N¹⁵²
Lachance G²⁵
Clarke R¹⁵³
Harris TB¹⁵⁴
Raitakari OT^{155, 156}
Attia JR^{52, 53, 157}
Van Heemst D²⁴
Kajantie E^{158, 159, 160}
Sorice R⁶⁷
Gambaro G¹⁶¹
Scott RA⁵⁷
Hicks AA⁷²
Ferrucci L⁹
Standl M⁷³
Lindgren CM^{75, 162, 163}
Starr JM^{76, 164}
Karlsson M¹⁶⁵
Lind L¹³⁴
Li JZ⁷⁹
Chambers JC^{80, 81, 166, 167, 168}
Mori TA⁸⁵
De Geus EJCN^{16, 17}
Heath AC¹⁴⁷
Martin NG¹⁸
Auvinen J^{150, 169}
Buckley BM¹⁷⁰
De Craen AJM²⁴
Waldenberger M^{40, 171}
Strauch K^{172, 173}
Meitinger T^{174, 175, 176}
Scott RJ^{52, 177}
Mcevoy M^{52, 53}
Beekman M⁵⁴
Bombieri C⁶⁸
Ridker PM^{11, 178}
Mohlke KL¹²
Pedersen NL¹³
Boomsma DI¹⁶
Whitfield JB¹⁸
Strachan DP¹⁷⁹
Hofman A¹
Vollenweider P¹⁸⁰
Cucca F²²
Jarvelin MR^{115, 150, 169, 181, 182}
Jukema JW^{23, 183, 184}
Spector TD²⁵
Hamsten A²⁸
Zeller T^{46, 48}
Uitterlinden AG^{1, 113}
Nauck M^{34, 185}
Gudnason V^{36, 37}
Qi L^{39, 186}
Grallert H^{40, 41}
Borecki IB¹⁸⁷
Rotter JI¹⁸⁸
Marz W^{44, 189, 190}
Wild PS^{48, 122, 191}
Lokki ML⁴⁹
Boyle M¹⁵⁷
Salomaa V⁵⁶
Melbye M^{58, 192, 193}
Eriksson JG^{56, 61, 78, 194}
Wilson JF^{62, 195}
Penninx BWJH⁴⁵
Becker DM¹⁰⁶
Worrall BB¹⁹⁶
Gibson G⁹⁹
Krauss RM¹⁹⁷
Ciullo M^{67, 128}
Zaza G¹⁹⁸
Wareham NJ⁵⁷
Oldehinkel AJ⁶⁹
Palmer LJ¹⁹⁹
Murray SS²⁰⁰
Pramstaller PP^{72, 201, 202}
Bandinelli S²⁰³
Heinrich J^{73, 204}
Ingelsson E^{205, 206, 207}
Deary IJ^{76, 208}
Magi R⁵
Vandenput L⁷⁸
Van Der Harst P³⁵
Desch KC²⁰⁹
Kooner JS^{81, 166, 168, 210}
Ohlsson C⁷⁸
Hayward C¹⁹⁵
Lehtimaki T^{50, 51}
Shuldiner AR⁸³
Arnett DK²¹¹
Beilin LJ⁸⁵
Robino A¹⁰⁷
Froguel P^{87, 212}
Pirastu M⁸⁹
Jess T²¹³
Loos RJF^{94, 95, 216}
Evans DA⁹³
Schmidt H^{217, 218}
Slagboom PE⁵⁴
Morris AP^{75, 219}
Psaty BM^{220, 221, 222, 223}
Visvikissiest S⁶
Reiner AP²²¹
Franco OH^{1, 228}
Benjamin EJ^{15, 229}
Dehghan A^{1, 181}

Source: American Journal of Human Genetics Published:2018

Abstract

C-reactive protein (CRP) is a sensitive biomarker of chronic low-grade inflammation and is associated with multiple complex diseases. The genetic determinants of chronic inflammation remain largely unknown, and the causal role of CRP in several clinical outcomes is debated. We performed two genome-wide association studies (GWASs), on HapMap and 1000 Genomes imputed data, of circulating amounts of CRP by using data from 88 studies comprising 204,402 European individuals. Additionally, we performed in silico functional analyses and Mendelian randomization analyses with several clinical outcomes. The GWAS meta-analyses of CRP revealed 58 distinct genetic loci (p < 5 × 10−8). After adjustment for body mass index in the regression analysis, the associations at all except three loci remained. The lead variants at the distinct loci explained up to 7.0% of the variance in circulating amounts of CRP. We identified 66 gene sets that were organized in two substantially correlated clusters, one mainly composed of immune pathways and the other characterized by metabolic pathways in the liver. Mendelian randomization analyses revealed a causal protective effect of CRP on schizophrenia and a risk-increasing effect on bipolar disorder. Our findings provide further insights into the biology of inflammation and could lead to interventions for treating inflammation and its clinical consequences. © 2018 American Society of Human Genetics

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Style	Citing Format
MLA	Ligthart S, et al.. "Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways That Link Inflammation and Complex Disorders." American Journal of Human Genetics, vol. 103, no. 5, 2018, pp. 691-706.
APA	Ligthart S, Vaez A, Vosa U, Stathopoulou MG, De Vries PS, Prins BP, Van Der Most PJ, Tanaka T, Naderi E, Rose LM, Wu Y, Karlsson R, Barbalic M, Lin H, Pool R, Zhu G, Mace A, Sidore C, Trompet S, ... Dehghan A (2018). Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways That Link Inflammation and Complex Disorders. American Journal of Human Genetics, 103(5), 691-706.
Chicago	Ligthart S, Vaez A, Vosa U, Stathopoulou MG, De Vries PS, Prins BP, Van Der Most PJ, et al.. "Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways That Link Inflammation and Complex Disorders." American Journal of Human Genetics 103, no. 5 (2018): 691-706.
Harvard	Ligthart S et al. (2018) 'Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways That Link Inflammation and Complex Disorders', American Journal of Human Genetics, 103(5), pp. 691-706.
Vancouver	Ligthart S, Vaez A, Vosa U, Stathopoulou MG, De Vries PS, Prins BP, et al.. Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways That Link Inflammation and Complex Disorders. American Journal of Human Genetics. 2018;103(5):691-706.
BibTex	@article{ author = {Ligthart S and Vaez A and Vosa U and Stathopoulou MG and De Vries PS and Prins BP and Van Der Most PJ and Tanaka T and Naderi E and Rose LM and Wu Y and Karlsson R and Barbalic M and Lin H and Pool R and Zhu G and Mace A and Sidore C and Trompet S and Mangino M and Sabaterlleal M and Kemp JP and Abbasi A and Kacprowski T and Verweij N and Smith AV and Huang T and Marzi C and Feitosa MF and Lohman KK and Kleber ME and Milaneschi Y and Mueller C and Huq M and Vlachopoulou E and Lyytikainen LP and Oldmeadow C and Deelen J and Perola M and Zhao JH and Feenstra B and Alizadeh BZ and Franke L and Snieder H and Amini M and Chasman DI and Ahluwalia TS and Tracy RP and Bis JC and Eiriksdottir G and Gross M and Dupuis J and Koenig W and Abbasi A and Nolte IM and Daveysmith G and Morrison AC and Boerwinkle E and Morris AP and Lahti J and Schraut KE and Fornage M and Suktitipat B and Chen WM and Li X and Nutile T and Malerba G and Luan J and Bak T and Schork N and Del Greco M F and Thiering E and Mahajan A and Marioni RE and Mihailov E and Ozel AB and Zhang W and Nethander M and Cheng YC and Aslibekyan S and Ang W and Gandin I and Yengo L and Portas L and Kooperberg C and Hofer E and Rajan KB and Schurmann C and Den Hollander W and Zhao J and Draisma HHM and Ford I and Timpson N and Teumer A and Huang H and Wahl S and Liu Y and Huang J and Uh HW and Geller F and Joshi PK and Yanek LR and Trabetti E and Lehne B and Vozzi D and Verbanck M and Biino G and Saba Y and Meulenbelt I and Oconnell JR and Laakso M and Giulianini F and Magnusson PKE and Ballantyne CM and Hottenga JJ and Montgomery GW and Rivadineira F and Rueedi R and Steri M and Herzig KH and Stott DJ and Menni C and Franberg M and St Pourcain B and Felix SB and Pers TH and Bakker SJL and Kraft P and Peters A and Vaidya D and Delgado G and Smit JH and Gromann V and Sinisalo J and Seppala I and Williams SR and Holliday EG and Moed M and Langenberg C and Raikkonen K and Ding J and Campbell H and Sale MM and Chen YDI and James AL and Ruggiero D and Soranzo N and Hartman CA and Smith EN and Berenson GS and Fuchsberger C and Tiesler CMT and Giedraitis V and Liewald D and Fischer K and Mellstrom D and Larsson A and Wang Y and Scott WR and Lorentzon M and Beilby J and Ryan KA and Pennell CE and Vuckovic D and Balkau B and Concas MP and Schmidt R and Mendes De Leon CF and Bottinger EP and Kloppenburg M and Paternoster L and Boehnke M and Musk AW and Willemsen G and Evans DM and Madden PAF and Kahonen M and Kutalik Z and Zoledziewska M and Karhunen V and Kritchevsky SB and Sattar N and Lachance G and Clarke R and Harris TB and Raitakari OT and Attia JR and Van Heemst D and Kajantie E and Sorice R and Gambaro G and Scott RA and Hicks AA and Ferrucci L and Standl M and Lindgren CM and Starr JM and Karlsson M and Lind L and Li JZ and Chambers JC and Mori TA and De Geus EJCN and Heath AC and Martin NG and Auvinen J and Buckley BM and De Craen AJM and Waldenberger M and Strauch K and Meitinger T and Scott RJ and Mcevoy M and Beekman M and Bombieri C and Ridker PM and Mohlke KL and Pedersen NL and Boomsma DI and Whitfield JB and Strachan DP and Hofman A and Vollenweider P and Cucca F and Jarvelin MR and Jukema JW and Spector TD and Hamsten A and Zeller T and Uitterlinden AG and Nauck M and Gudnason V and Qi L and Grallert H and Borecki IB and Rotter JI and Marz W and Wild PS and Lokki ML and Boyle M and Salomaa V and Melbye M and Eriksson JG and Wilson JF and Penninx BWJH and Becker DM and Worrall BB and Gibson G and Krauss RM and Ciullo M and Zaza G and Wareham NJ and Oldehinkel AJ and Palmer LJ and Murray SS and Pramstaller PP and Bandinelli S and Heinrich J and Ingelsson E and Deary IJ and Magi R and Vandenput L and Van Der Harst P and Desch KC and Kooner JS and Ohlsson C and Hayward C and Lehtimaki T and Shuldiner AR and Arnett DK and Beilin LJ and Robino A and Froguel P and Pirastu M and Jess T and Loos RJF and Evans DA and Schmidt H and Slagboom PE and Morris AP and Psaty BM and Visvikissiest S and Reiner AP and Franco OH and Benjamin EJ and Dehghan A}, title = {Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways That Link Inflammation and Complex Disorders}, journal = {American Journal of Human Genetics}, volume = {103}, number = {5}, pages = {691-706}, year = {2018} }
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Style

Citing Format

MLA

Ligthart S, et al.. "Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways That Link Inflammation and Complex Disorders." American Journal of Human Genetics, vol. 103, no. 5, 2018, pp. 691-706.

APA

Ligthart S, Vaez A, Vosa U, Stathopoulou MG, De Vries PS, Prins BP, Van Der Most PJ, Tanaka T, Naderi E, Rose LM, Wu Y, Karlsson R, Barbalic M, Lin H, Pool R, Zhu G, Mace A, Sidore C, Trompet S, ... Dehghan A (2018). Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways That Link Inflammation and Complex Disorders. American Journal of Human Genetics, 103(5), 691-706.

Chicago

Ligthart S, Vaez A, Vosa U, Stathopoulou MG, De Vries PS, Prins BP, Van Der Most PJ, et al.. "Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways That Link Inflammation and Complex Disorders." American Journal of Human Genetics 103, no. 5 (2018): 691-706.

Harvard

Ligthart S et al. (2018) 'Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways That Link Inflammation and Complex Disorders', American Journal of Human Genetics, 103(5), pp. 691-706.

Vancouver

Ligthart S, Vaez A, Vosa U, Stathopoulou MG, De Vries PS, Prins BP, et al.. Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways That Link Inflammation and Complex Disorders. American Journal of Human Genetics. 2018;103(5):691-706.

BibTex

@article{ author = {Ligthart S and Vaez A and Vosa U and Stathopoulou MG and De Vries PS and Prins BP and Van Der Most PJ and Tanaka T and Naderi E and Rose LM and Wu Y and Karlsson R and Barbalic M and Lin H and Pool R and Zhu G and Mace A and Sidore C and Trompet S and Mangino M and Sabaterlleal M and Kemp JP and Abbasi A and Kacprowski T and Verweij N and Smith AV and Huang T and Marzi C and Feitosa MF and Lohman KK and Kleber ME and Milaneschi Y and Mueller C and Huq M and Vlachopoulou E and Lyytikainen LP and Oldmeadow C and Deelen J and Perola M and Zhao JH and Feenstra B and Alizadeh BZ and Franke L and Snieder H and Amini M and Chasman DI and Ahluwalia TS and Tracy RP and Bis JC and Eiriksdottir G and Gross M and Dupuis J and Koenig W and Abbasi A and Nolte IM and Daveysmith G and Morrison AC and Boerwinkle E and Morris AP and Lahti J and Schraut KE and Fornage M and Suktitipat B and Chen WM and Li X and Nutile T and Malerba G and Luan J and Bak T and Schork N and Del Greco M F and Thiering E and Mahajan A and Marioni RE and Mihailov E and Ozel AB and Zhang W and Nethander M and Cheng YC and Aslibekyan S and Ang W and Gandin I and Yengo L and Portas L and Kooperberg C and Hofer E and Rajan KB and Schurmann C and Den Hollander W and Zhao J and Draisma HHM and Ford I and Timpson N and Teumer A and Huang H and Wahl S and Liu Y and Huang J and Uh HW and Geller F and Joshi PK and Yanek LR and Trabetti E and Lehne B and Vozzi D and Verbanck M and Biino G and Saba Y and Meulenbelt I and Oconnell JR and Laakso M and Giulianini F and Magnusson PKE and Ballantyne CM and Hottenga JJ and Montgomery GW and Rivadineira F and Rueedi R and Steri M and Herzig KH and Stott DJ and Menni C and Franberg M and St Pourcain B and Felix SB and Pers TH and Bakker SJL and Kraft P and Peters A and Vaidya D and Delgado G and Smit JH and Gromann V and Sinisalo J and Seppala I and Williams SR and Holliday EG and Moed M and Langenberg C and Raikkonen K and Ding J and Campbell H and Sale MM and Chen YDI and James AL and Ruggiero D and Soranzo N and Hartman CA and Smith EN and Berenson GS and Fuchsberger C and Tiesler CMT and Giedraitis V and Liewald D and Fischer K and Mellstrom D and Larsson A and Wang Y and Scott WR and Lorentzon M and Beilby J and Ryan KA and Pennell CE and Vuckovic D and Balkau B and Concas MP and Schmidt R and Mendes De Leon CF and Bottinger EP and Kloppenburg M and Paternoster L and Boehnke M and Musk AW and Willemsen G and Evans DM and Madden PAF and Kahonen M and Kutalik Z and Zoledziewska M and Karhunen V and Kritchevsky SB and Sattar N and Lachance G and Clarke R and Harris TB and Raitakari OT and Attia JR and Van Heemst D and Kajantie E and Sorice R and Gambaro G and Scott RA and Hicks AA and Ferrucci L and Standl M and Lindgren CM and Starr JM and Karlsson M and Lind L and Li JZ and Chambers JC and Mori TA and De Geus EJCN and Heath AC and Martin NG and Auvinen J and Buckley BM and De Craen AJM and Waldenberger M and Strauch K and Meitinger T and Scott RJ and Mcevoy M and Beekman M and Bombieri C and Ridker PM and Mohlke KL and Pedersen NL and Boomsma DI and Whitfield JB and Strachan DP and Hofman A and Vollenweider P and Cucca F and Jarvelin MR and Jukema JW and Spector TD and Hamsten A and Zeller T and Uitterlinden AG and Nauck M and Gudnason V and Qi L and Grallert H and Borecki IB and Rotter JI and Marz W and Wild PS and Lokki ML and Boyle M and Salomaa V and Melbye M and Eriksson JG and Wilson JF and Penninx BWJH and Becker DM and Worrall BB and Gibson G and Krauss RM and Ciullo M and Zaza G and Wareham NJ and Oldehinkel AJ and Palmer LJ and Murray SS and Pramstaller PP and Bandinelli S and Heinrich J and Ingelsson E and Deary IJ and Magi R and Vandenput L and Van Der Harst P and Desch KC and Kooner JS and Ohlsson C and Hayward C and Lehtimaki T and Shuldiner AR and Arnett DK and Beilin LJ and Robino A and Froguel P and Pirastu M and Jess T and Loos RJF and Evans DA and Schmidt H and Slagboom PE and Morris AP and Psaty BM and Visvikissiest S and Reiner AP and Franco OH and Benjamin EJ and Dehghan A}, title = {Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways That Link Inflammation and Complex Disorders}, journal = {American Journal of Human Genetics}, volume = {103}, number = {5}, pages = {691-706}, year = {2018} }

RIS

TY - JOUR
AU - Ligthart S
AU - Vaez A
AU - Vosa U
AU - Stathopoulou MG
AU - De Vries PS
AU - Prins BP
AU - Van Der Most PJ
AU - Tanaka T
AU - Naderi E
AU - Rose LM
AU - Wu Y
AU - Karlsson R
AU - Barbalic M
AU - Lin H
AU - Pool R
AU - Zhu G
AU - Mace A
AU - Sidore C
AU - Trompet S
AU - Mangino M
AU - Sabaterlleal M
AU - Kemp JP
AU - Abbasi A
AU - Kacprowski T
AU - Verweij N
AU - Smith AV
AU - Huang T
AU - Marzi C
AU - Feitosa MF
AU - Lohman KK
AU - Kleber ME
AU - Milaneschi Y
AU - Mueller C
AU - Huq M
AU - Vlachopoulou E
AU - Lyytikainen LP
AU - Oldmeadow C
AU - Deelen J
AU - Perola M
AU - Zhao JH
AU - Feenstra B
AU - Alizadeh BZ
AU - Franke L
AU - Snieder H
AU - Amini M
AU - Chasman DI
AU - Ahluwalia TS
AU - Tracy RP
AU - Bis JC
AU - Eiriksdottir G
AU - Gross M
AU - Dupuis J
AU - Koenig W
AU - Abbasi A
AU - Nolte IM
AU - Daveysmith G
AU - Morrison AC
AU - Boerwinkle E
AU - Morris AP
AU - Lahti J
AU - Schraut KE
AU - Fornage M
AU - Suktitipat B
AU - Chen WM
AU - Li X
AU - Nutile T
AU - Malerba G
AU - Luan J
AU - Bak T
AU - Schork N
AU - Del Greco M F
AU - Thiering E
AU - Mahajan A
AU - Marioni RE
AU - Mihailov E
AU - Ozel AB
AU - Zhang W
AU - Nethander M
AU - Cheng YC
AU - Aslibekyan S
AU - Ang W
AU - Gandin I
AU - Yengo L
AU - Portas L
AU - Kooperberg C
AU - Hofer E
AU - Rajan KB
AU - Schurmann C
AU - Den Hollander W
AU - Zhao J
AU - Draisma HHM
AU - Ford I
AU - Timpson N
AU - Teumer A
AU - Huang H
AU - Wahl S
AU - Liu Y
AU - Huang J
AU - Uh HW
AU - Geller F
AU - Joshi PK
AU - Yanek LR
AU - Trabetti E
AU - Lehne B
AU - Vozzi D
AU - Verbanck M
AU - Biino G
AU - Saba Y
AU - Meulenbelt I
AU - Oconnell JR
AU - Laakso M
AU - Giulianini F
AU - Magnusson PKE
AU - Ballantyne CM
AU - Hottenga JJ
AU - Montgomery GW
AU - Rivadineira F
AU - Rueedi R
AU - Steri M
AU - Herzig KH
AU - Stott DJ
AU - Menni C
AU - Franberg M
AU - St Pourcain B
AU - Felix SB
AU - Pers TH
AU - Bakker SJL
AU - Kraft P
AU - Peters A
AU - Vaidya D
AU - Delgado G
AU - Smit JH
AU - Gromann V
AU - Sinisalo J
AU - Seppala I
AU - Williams SR
AU - Holliday EG
AU - Moed M
AU - Langenberg C
AU - Raikkonen K
AU - Ding J
AU - Campbell H
AU - Sale MM
AU - Chen YDI
AU - James AL
AU - Ruggiero D
AU - Soranzo N
AU - Hartman CA
AU - Smith EN
AU - Berenson GS
AU - Fuchsberger C
AU - Tiesler CMT
AU - Giedraitis V
AU - Liewald D
AU - Fischer K
AU - Mellstrom D
AU - Larsson A
AU - Wang Y
AU - Scott WR
AU - Lorentzon M
AU - Beilby J
AU - Ryan KA
AU - Pennell CE
AU - Vuckovic D
AU - Balkau B
AU - Concas MP
AU - Schmidt R
AU - Mendes De Leon CF
AU - Bottinger EP
AU - Kloppenburg M
AU - Paternoster L
AU - Boehnke M
AU - Musk AW
AU - Willemsen G
AU - Evans DM
AU - Madden PAF
AU - Kahonen M
AU - Kutalik Z
AU - Zoledziewska M
AU - Karhunen V
AU - Kritchevsky SB
AU - Sattar N
AU - Lachance G
AU - Clarke R
AU - Harris TB
AU - Raitakari OT
AU - Attia JR
AU - Van Heemst D
AU - Kajantie E
AU - Sorice R
AU - Gambaro G
AU - Scott RA
AU - Hicks AA
AU - Ferrucci L
AU - Standl M
AU - Lindgren CM
AU - Starr JM
AU - Karlsson M
AU - Lind L
AU - Li JZ
AU - Chambers JC
AU - Mori TA
AU - De Geus EJCN
AU - Heath AC
AU - Martin NG
AU - Auvinen J
AU - Buckley BM
AU - De Craen AJM
AU - Waldenberger M
AU - Strauch K
AU - Meitinger T
AU - Scott RJ
AU - Mcevoy M
AU - Beekman M
AU - Bombieri C
AU - Ridker PM
AU - Mohlke KL
AU - Pedersen NL
AU - Boomsma DI
AU - Whitfield JB
AU - Strachan DP
AU - Hofman A
AU - Vollenweider P
AU - Cucca F
AU - Jarvelin MR
AU - Jukema JW
AU - Spector TD
AU - Hamsten A
AU - Zeller T
AU - Uitterlinden AG
AU - Nauck M
AU - Gudnason V
AU - Qi L
AU - Grallert H
AU - Borecki IB
AU - Rotter JI
AU - Marz W
AU - Wild PS
AU - Lokki ML
AU - Boyle M
AU - Salomaa V
AU - Melbye M
AU - Eriksson JG
AU - Wilson JF
AU - Penninx BWJH
AU - Becker DM
AU - Worrall BB
AU - Gibson G
AU - Krauss RM
AU - Ciullo M
AU - Zaza G
AU - Wareham NJ
AU - Oldehinkel AJ
AU - Palmer LJ
AU - Murray SS
AU - Pramstaller PP
AU - Bandinelli S
AU - Heinrich J
AU - Ingelsson E
AU - Deary IJ
AU - Magi R
AU - Vandenput L
AU - Van Der Harst P
AU - Desch KC
AU - Kooner JS
AU - Ohlsson C
AU - Hayward C
AU - Lehtimaki T
AU - Shuldiner AR
AU - Arnett DK
AU - Beilin LJ
AU - Robino A
AU - Froguel P
AU - Pirastu M
AU - Jess T
AU - Loos RJF
AU - Evans DA
AU - Schmidt H
AU - Slagboom PE
AU - Morris AP
AU - Psaty BM
AU - Visvikissiest S
AU - Reiner AP
AU - Franco OH
AU - Benjamin EJ
AU - Dehghan A
TI - Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways That Link Inflammation and Complex Disorders
JO - American Journal of Human Genetics
VL - 103
IS - 5
SP - 691
EP - 706
PY - 2018
ER -

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