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Efficacy of the Malva Sylvestris L. Flowers Aqueous Extract for Functional Constipation: A Placebo-Controlled Trial Publisher Pubmed



Elsagh M1 ; Fartookzadeh MR2 ; Kamalinejad M3 ; Anushiravani M4 ; Feizi A5 ; Behbahani FA1 ; Rafiei R6 ; Arjmandpour A6 ; Adibi P7
Authors

Source: Complementary Therapies in Clinical Practice Published:2015


Abstract

Objective: To evaluate the efficacy of Malva sylvestris L. flowers extract for treatment of FC. Method: Adults with FC were allocated to receive the M.sylvestris L. flowers aqueous extract syrup (MSL, 1g extract/day) or placebo for four weeks. Frequency of constipation symptoms and stool forms were assessed every week. Self-reported improvement was assessed after treatment. Results: Compared with placebo, more increase was observed in defecation frequency (F=18.8, P<0.001) and more decrease was observed in frequency of all constipation symptoms by MSL (F=16.5 to 25.3, all P values <0.001). Also, the MSL group experienced more reduction in frequency of hard stool forms (45.4% vs. 9.1%, P<0.001) and reported more improvement in all symptoms (all P values <0.01) than placebo. Conclusion: The M.sylvestris L. flowers aqueous extract is efficacious and safe for the treatment of FC in adult patients. Investigating the mechanisms of action is warranted. IRCT2014031617032N1. © 2015 Elsevier Ltd.
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