Isfahan University of Medical Sciences

Science Communicator Platform

Share By
Hypothyroidism in First‑Degree Relatives of Neonates With Congenital Hypothyroidism: Is There an Association? Publisher

Summary: What predicts persistent congenital hypothyroidism? A study linked family thyroid history with persistent cases, but found no clear association with parental consanguinity. #Thyroid #NewbornHealth

Heidarpour M ; Omoomi S ; Vakilbashi O ; Taki A ; Hovsepian S
Authors

Source: International Journal of Preventive Medicine Published:2023


Abstract

Background: Recent studies have shown an increased incidence of congenital hypothyroidism (CH), especially in the middle‑east region. The exact etiology is unknown; however, it has been related to several factors, the most noticeable being the high prevalence of transient CH (TCH), parental consanguinity, and the history of hypothyroidism in relatives. We sought to determine the impact of hypothyroidism in the relatives of patients with the observed trend. Methods: We included all patients with primary CH detected through the Newborn Screening (NBS) Program from 2007 to 2016. We analyzed the impact of consanguinity relationship, parental and siblings’ thyroid function, second‑degree relatives’ thyroid function, parental educational level, age, and maternal gestational diabetes on the development of permanent CH (PCH) and TCH. Results: A total of 1447 consecutive eligible patients were recruited during the study period. Of this number, 1171 (81%) were diagnosed with CH: 623 (53.2%) had PCH and 548 (46.8%) had TCH. Six hundred thirty‑three (54.1%) participants were men, and 814 (69.5%) had a history of relatives’ hypothyroidism. Our data analysis revealed a significant difference regarding the male gender, having a history of relatives’ hypothyroidism, and parental hypothyroidism compared to TCH ones (P < 0.05). Patients with a history of relatives’ hypothyroidism had significantly higher PCH than TCH (P < 0.0001). However, consanguineous marriage was not comparable in patients regardless of their history of relatives’ hypothyroidism (P‑value >0.884). Conclusions: Our findings indicated the role of the history of hypothyroidism in neonates’ relatives in the evolution of the PCH. Meanwhile, consanguineous marriage did not impress the development of PCH and TCH. © 2023 International Journal of Preventive Medicine.
Related Docs
View other Related Docs
1. Epidemiology of Neonatal Congenital Hypothyroidism During 2011-2017, Journal of Critical Reviews (2020)
2. The Prevalence of Thyroid Dysfunction in an Iodine-Sufficient Area in Iran, Archives of Iranian Medicine (2009)
3. Relative Frequency of Thyroid Disorders in Pregnant Women at a Maternity Clinic in Isfahan, Iran, Journal of Isfahan Medical School (2012)
Experts (# of related papers)
View all Related Experts
Mahin Hashemipour (9)
Silva Hovsepian (8)
Hypothyroidism in First‑Degree Relatives of Neonates With Congenital Hypothyroidism: Is There an Association?
Other Related Docs
4. Association Between Different Metabolic Phenotypes and the Development of Hypothyroidism: 9 Years Follow-Up of Tehran Thyroid Study, Frontiers in Endocrinology (2023)
5. Congenital Hypothyroidism; Is There Any Familial Component?, Journal of Isfahan Medical School (2009)
6. Thyroid Function Abnormalities Among First-Degree Relatives of Iranian Congenital Hypothyroidism Neonates, Pediatrics International (2010)
7. Parental Consanguinity Among Parents of Neonates With Congenital Hypothyroidism in Isfahan, Eastern Mediterranean Health Journal (2007)
8. The Tsh Levels and Risk of Hypothyroidism: Results From a Population Based Prospective Cohort Study in an Iranian Adult's Population, European Journal of Internal Medicine (2017)
9. Incidence and Risk Factors of Hypothyroidism in Patients With Hematological Malignancies Compared to Healthy Population: A Systematic Review and Meta-Analysis, BMC Cancer (2025)
10. Thyroid Abnormalities Among First-Degree Relatives of Children With Congenital Hypothyroidism: An Ultrasound Survey, Hormone Research (2008)
11. Prevalence of Permanent Congenital Hypothyroidism in Isfahan-Iran, International Journal of Preventive Medicine (2013)
12. Comparison of Severity of Osteoporosis in Women With Primary Hypothyroidism and Healthy Women, Journal of Isfahan Medical School (2012)
13. Congenital Hypothyroidism in Different Cities of the Isfahan Province: A Descriptive Retrospective Study, Journal of Education and Health Promotion (2019)
14. The Role of Maternal Tsh Receptor Blocking Antibody in the Etiology of Congenital Hypothyroidism in Isfahan, Journal of Isfahan Medical School (2011)
15. Incidence of Thyroid Dysfunction in an Iranian Adult Population: The Predictor Role of Thyroid Autoantibodies: Results From a Prospective Population-Based Cohort Study, European Journal of Medical Research (2017)
16. Risk Factors for Thyroid Dysfunction in Pregnancy: An Individual Participant Data Meta-Analysis, Thyroid (2024)
17. Permanent and Transient Congenital Hypothyroidism in Isfahan-Iran, Journal of Medical Screening (2009)
18. Prevalence of Transient Congenital Hypothyroidism in Central Part of Iran, Journal of Research in Medical Sciences (2013)
19. The Relationship Between Hypothyroidism and Preeclampsia in Pregnant Women in an Iranian Sample, Journal of Isfahan Medical School (2017)
20. Prevalence of Overt Hypothyroidism and Subclinical Hypothyroidism in Metabolic Syndrome: A Systematic Review and Meta-Analysis, BMC Endocrine Disorders (2026)