Isfahan University of Medical Sciences

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Effects of Treadmill Running on Extracellular Basal Levels of Glutamate and Gaba at Dentate Gyrus of Streptozotocin-Induced Diabetic Rats



Reisi P1 ; Alaei H1 ; Babri S2 ; Sharifi MR1 ; Mohaddes G3 ; Soleimannejad E4 ; Rashidi B5
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Source: Journal of Research in Medical Sciences Published:2010

Abstract

BACKGROUND: The present study evaluated the effects of treadmill running on extracellular basal levels of glutamate and GABA at dentate gyrus of streptozotocin-induced diabetic rats. METHODS: After 12 weeks of diabetes induction and exercise period, extracellular levels of glutamate and GABA were investigated. RESULTS: The results showed that glutamate levels were significantly decreased in diabetes-rest group comparing to the control-rest and the diabetes-exercise groups. CONCLUSIONS: The findings support the possibility that treadmill running is helpful in alleviating neurotransmitter homeostasis and alterations in transmission in diabetes mellitus.
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