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Bioactivity-Guided Isolation of New Antiproliferative Compounds From Juniperus Foetidissima Willd Publisher Pubmed

Summary: Research shows juniper compounds fight ovary and bladder cancer cells, suggesting new treatment possibilities. #CancerResearch #PlantMedicine

Rafieiankopaei M1 ; Suleimani Dehkordi I2 ; Ghanadian M3, 4 ; Shokrollahi A2 ; Aghaei M3 ; Ayatollahi SA5 ; Choudhary MI6, 7
Authors

Source: Natural Product Research Published:2016


Abstract

Based on a literature survey on cytotoxic medicinal plants, Juniper species were identified as interesting source of antitumor compounds. Using bioassay-guided fractionation against Caov-4 cancer cells on acetone extract of leaves and branchlets of Juniperus foetidissima led to the isolation of a new 3H-benzofuaran-2-one: 4-methyl-3-methoxy-3H-benzofuaran-2-one (1), a new sesquiterpene: 4,9(α)-dihydroxy-nardosin-6-en (2) and an already known labdane-type diterpene: 15-hydroxy-8(17),13(E)-labdadiene-19-carboxilic acid (3). Compounds 1–3 exhibited cytotoxic effects, with moderate cytotoxicity against the EJ-138 bladder and CAOV-4 ovary cancer cell lines. © 2015 Taylor & Francis.
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Bioactivity-Guided Isolation of New Antiproliferative Compounds From Juniperus Foetidissima Willd
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