Role of Long Noncoding Rnas in Pathological Cardiac Remodeling After Myocardial Infarction: An Emerging Insight Into Molecular Mechanisms and Therapeutic Potential Publisher Pubmed

Summary: Review highlights long non-coding RNAs as key players in heart remodeling post-myocardial infarction, offering new treatment targets. #HeartFailure #lncRNAs

Yaghoobi A^{1, 2} ; Rezaee M^{1, 2} ; Behnoush AH¹ ; Khalaji A¹ ; Mafi A³ ; Houjaghan AK⁴ ; Masoudkabir F¹ ; Pahlavan S⁵
Source: Biomedicine and Pharmacotherapy Published:2024

Abstract

Myocardial infarction (MI) is the leading cause of heart failure (HF), accounting for high mortality and morbidity worldwide. As a consequence of ischemia/reperfusion injury during MI, multiple cellular processes such as oxidative stress-induced damage, cardiomyocyte death, and inflammatory responses occur. In the next stage, the proliferation and activation of cardiac fibroblasts results in myocardial fibrosis and HF progression. Therefore, developing a novel therapeutic strategy is urgently warranted to restrict the progression of pathological cardiac remodeling. Recently, targeting long non-coding RNAs (lncRNAs) provided a novel insight into treating several disorders. In this regard, numerous investigations have indicated that several lncRNAs could participate in the pathogenesis of MI-induced cardiac remodeling, suggesting their potential therapeutic applications. In this review, we summarized lncRNAs displayed in the pathophysiology of cardiac remodeling after MI, emphasizing molecular mechanisms. Also, we highlighted the possible translational role of lncRNAs as therapeutic targets for this condition and discussed the potential role of exosomes in delivering the lncRNAs involved in post-MI cardiac remodeling. © 2024 The Authors