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High-Salt Intake During Pregnancy May Influence the Outcome of Renal Ischemia/Reperfusion in in Adult Offspring Publisher



Shahzamani F1, 2 ; Monajemi R2 ; Nematbakhsh M1, 3, 4
Authors

Source: Journal of Renal Injury Prevention Published:2018


Abstract

Introduction: The salt diet during the pregnancy may disturb the adult offspring's organs functions. Objectives: This study was designed to determine the role of high salt intake during pregnancy on the outcome of renal ischemia reperfusion (IR) in adult offspring. Materials and Methods: Renal IR was induced in 55 adult male and female offspring from mothers who intake high salt or normal drinking water during pregnancy, and the kidney function was evaluated. Results: Salt intake during pregnancy increased the serum levels of creatinine (Cr) and blood urea nitrogen (BUN) and decreased creatinine clearances (ClCr) level in offspring after renal IR gender dependently. Conclusion: The structural change in kidney of offspring from mothers who were subjected to salt intake during pregnancy may influence the outcomes of offspring's kidney functions after renal IR. © 2018 The Author(s).
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