Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Coagulation Factor Xiii-A A614t Gene Variation Is Suggestive of Founder Effect in Iranian Patients With Sever Congenital Factor Xiii Deficiency Publisher



Naderi M1 ; Tabibian S2 ; Alizadeh S2 ; Abtahi ZS2 ; Dorgalaleh A3
Authors

Source: Journal of Cellular and Molecular Anesthesia Published:2016


Abstract

Background: Factor XIII (FXIII) is a heterotetramer consisting of two subunits, FXIII-A and FXIII-B. Several common gene variations were observed in FXIII-A gene with obvious ethnic difference. This study assessed prevalence of A614T as a common FXIII-A gene variation among Iranian patients with FXIII deficiency (FXIIID). Materials and Methods: This study was conducted on eighty Iranian unrelated individuals with FXIIID. Genotype analysis for FXIII-A A614T gene variation was performed for all individuals. Results: Molecular analysis of these Iranian populations revealed that all studied patients were homozygous for T allele at codon 204 of FXIII-A1 subunit. Conclusion: Present of T allele at codon 204 of FXIII-A1 subunit among all study population can be suggestive of founder effect. © 2016 Shahid Beheshti University of Medical Sciences,  Anesthesiology Research Center. All Rights Reserved.
Other Related Docs
5. Guidelines for Laboratory Diagnosis of Factor Xiii Deficiency, Blood Coagulation and Fibrinolysis (2016)
9. Frequency of M287t/As3mt Single Nucleotide Polymorphism in an Iranian Population, International Journal of Hematology-Oncology and Stem Cell Research (2017)
14. Association Between Rs6759298 and Ankylosing Spondylitis in Iranian Population, Avicenna Journal of Medical Biotechnology (2018)
16. A Novel Tecta Mutation Causes Arnshl, International Journal of Pediatric Otorhinolaryngology (2017)
17. Genotype and Allele Frequency of Cyp2c19*17 in a Healthy Iranian Population, Medical Journal of the Islamic Republic of Iran (2015)