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Cancer Chemo-Preventive Effects of Red Propolis: A System Biology Approach Publisher



Vafaee R1 ; Azodi MZ2 ; Rezaeitavirani M3 ; Razzaghi Z1 ; Arjmand B4 ; Esmaeili S5
Authors

Source: Research Journal of Pharmacognosy Published:2023


Abstract

Background and objectives: Propolis is a natural product of honey bees that is characterized by therapeutic effects on diverse diseases. To elucidate the molecular mechanism of propolis effects on tumor, protein-protein interaction (PPI) network analysis of proteome data of Hep-2 cells treated with red propolis was conducted. Methods: Cytoscape V 3.9.1 and its plug-ins evaluated the differentially expressed proteins (DEPs) in terms of network construction and the corresponding topological features. Results: The results implied that six hub-bottlenecks including ACTB, GAPDH, HSP90AA1, HSPA8, HSP90AB1, and HSPA5 were present in the PPI network; however, only the last central protein was among DEPs. ClueGO+ CluePedia identified five related biological processes and three action types of their connections. Results refer to anticancer property of red propolis. Conclusion: The proposed crucial proteins and their linked biological processes may represent as key players in the anticancer underlying mechanism of red propolis. © 2023. Open access.
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