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Genetic Characterization of G Protein in Respiratory Syncytial Virus On-1 Genotype in Tehran Publisher



Malekshahi SS1 ; Samieipour Y2 ; Rahbarimanesh AA3 ; Izadi A3 ; Ghavami N2 ; Razaghipour S4 ; Naseri M2 ; Mokhtariazad T2 ; Salimi V2
Authors

Source: Future Virology Published:2020


Abstract

Aim: We investigated the genetic characterization of the respiratory syncytial virus (RSV) ON-1 genotypes and their different lineages based on the G gene among children <2 years of age presenting with acute respiratory tract infections in Tehran, Iran. Materials methods: A phylogenetic tree from the Iranian samples and ON-1 strains of various parts of the world were constructed. The amino acid composition of the RSV G protein of the ON-1 genotype was mapped. Results: Human RSV ON-1 genotypes from the Iranian samples clustered in three lineages. The most common amino acid substitutions were as follows: X218Q, I240S, L289P, Y304H and L310P. Conclusion: Continuing molecular epidemiological surveys in other regions of Iran will provide deeper insight into the nature of this replacement of the dominant RSV genotype from GA2 to ON-1 in Iran. © 2020 Future Medicine Ltd.. All rights reserved.
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