The Toxicity of Saffron (Crocus Sativus L.) and Its Constituents Against Normal and Cancer Cells Publisher



Milajerdi A¹ ; Djafarian K² ; Hosseini B¹
Source: Journal of Nutrition and Intermediary Metabolism Published:2016

Abstract

Background and aims Saffron is a spice with preventive and curative effects. This study aimed to review the toxicity of saffron extract and its constituents on normal and cancer cells. Methods We searched the PubMed, Science direct, SID and Magiran databases up to November 2015 using the following key words: Toxicity, saffron, crocin, crocetin, safranal, cancer. Finally, 73 English and 5 Persian articles were selected to be recruited to be reviewed. Results Saffron has selective toxicity against cancer cells, through inhibition of RNA and DNA synthesis and increasing apoptosis. Crocin has been considered as the most important anticancer agent of saffron that plays a role in gene expression and apoptosis in cancer cells. Crocetin has an inhibitory effect on the cancer cells growth that may be due to reduced synthesis of DNA, RNA and protein in neoplastic cells, RNA polymerase II inhibition, and interaction with histone H1 and H1-DNA structures. Saffron and its crocin and crocetin have also shown anticancer and cancer-preventive effects in animal models of cancer. Safranal also has shown antitumor activity with low toxicity. On the other hand, the lethal dose of 50% (LD50) for the saffron and its constituents against normal cells can be very high. Conclusion In conclusion, emerging evidence suggests that saffron extract and its crocin, crocetin and safranal have a selective toxicity effects against cancer cells and also may have cancer preventive functions. However, Saffron and its constituent's toxicity against normal cells is negligible and they are even non-toxic in oral administration. © 2016 The Authors. Published by Elsevier Inc.