Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Regulation of Autophagy by Polyphenols: Paving the Road for Treatment of Neurodegeneration Publisher Pubmed



Nabavi SF1 ; Sureda A2 ; Dehpour AR3, 4 ; Shirooie S5 ; Silva AS6, 7 ; Devi KP8 ; Ahmed T9 ; Ishaq N9 ; Hashim R9 ; Sobarzosanchez E10, 11 ; Daglia M12 ; Braidy N13, 16 ; Volpicella M14 ; Vacca RA15 Show All Authors
Authors
  1. Nabavi SF1
  2. Sureda A2
  3. Dehpour AR3, 4
  4. Shirooie S5
  5. Silva AS6, 7
  6. Devi KP8
  7. Ahmed T9
  8. Ishaq N9
  9. Hashim R9
  10. Sobarzosanchez E10, 11
  11. Daglia M12
  12. Braidy N13, 16
  13. Volpicella M14
  14. Vacca RA15
  15. Nabavi SM1, 17

Source: Biotechnology Advances Published:2018


Abstract

In the present paper, we will discuss on the importance of autophagy in the central nervous system, and outline the relation between autophagic pathways and the pathogenesis of neurodegenerative disorders. The potential therapeutic benefits of naturally occurring phytochemicals as pharmacological modulators of autophagy will also be addressed. Our findings provide renewed insight on the molecular modes of protection by polyphenols, which is likely to be at least in part mediated not only by their potent antioxidant and anti-inflammatory effects, but also through modulation of autophagic processes to remove the aberrant protein aggregates. © 2017 Elsevier Inc.
Other Related Docs
6. Novel Therapeutic Strategies for Stroke: The Role of Autophagy, Critical Reviews in Clinical Laboratory Sciences (2019)
7. Exosomes, Autophagy and Er Stress Pathways in Human Diseases: Cross-Regulation and Therapeutic Approaches, Biochimica et Biophysica Acta - Molecular Basis of Disease (2022)
10. Cell Death Pathways and Viruses: Role of Micrornas, Molecular Therapy Nucleic Acids (2021)
15. Nanoformulations of Herbal Extracts in Treatment of Neurodegenerative Disorders, Frontiers in Bioengineering and Biotechnology (2020)
19. Autophagy in Alzheimer's Disease, Reviews in the Neurosciences (2015)