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Physicochemical Characteristics of Liposomes Are Decisive for Their Antirestenosis Efficacy Following Local Delivery Publisher Pubmed



Haeri A1 ; Sadeghian S2 ; Rabbani S2 ; Shirani S2 ; Anvari MS2 ; Dadashzadeh S1, 3
Authors

Source: Nanomedicine Published:2017


Abstract

Aim: To develop an ameliorated sirolimus (SIR) liposome for intramural delivery, the effects of various carrier physicochemical parameters on the antirestenosis efficacy were evaluated. Materials & methods: Different liposomes were prepared, characterized and administered to balloon injured rats (12 animal groups). Their efficacies were investigated using morphometric, immunohistochemical and in vivo computed tomography imaging analyses. Results: The antirestenosis efficacy of SIR liposomes decreased in the following order: cationic 100 nm vesicles ≥ cationic 60 nm vesicles > neutral 100 nm vesicles ≥ stealth 100 nm vesicles > anionic 100 nm vesicles. The 100 μg SIR loaded in cationic liposomes showed almost no artery stenosis. Conclusion: Appropriate modulation of physicochemical characteristics makes it possible to optimize the liposomes for local delivery. © 2017 Future Medicine Ltd.
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