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Anti-Diabetic Effect of Β-D-Mannuronic Acid (M2000) As a Novel Nsaid With Immunosuppressive Property on Insulin Production, Blood Glucose, and Inflammatory Markers in the Experimental Diabetes Model Publisher Pubmed



Mortazavijahromi SS1, 2 ; Alizadeh S3 ; Javanbakht MH3 ; Mirshafiey A1
Authors

Source: Archives of Physiology and Biochemistry Published:2019


Abstract

This research aimed to evaluate the anti-diabetic effects of β-d-mannuronic acid (M2000) on blood glucose, insulin production, and inflammatory markers in streptozotocin-induced diabetic rats. Our data showed that the final fasting serum glucose level was significantly lower in the M2000-treated group compared to the diabetic control group (p <.05). In addition, the final fasting serum insulin level significantly increased in the M2000-treated group compared to the diabetic control group (p <.05). Our finding revealed that the serum level of hs-CRP and IL-6 decreased significantly in the M2000-treated group compared to the diabetic control group (p <.05). This study showed that M2000, as a new NSAID, was able to decrease serum glucose levels and increase serum insulin levels and this drug could significantly decrease the inflammatory markers in the M2000-treated group. Collectively, treatment with M2000 might be recommended reducing the severity of diabetes-induced inflammatory symptoms. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
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