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Evidence-Based Guidelines for the Pharmacological Treatment of Migraine Publisher Pubmed



Ornello R1 ; Caponnetto V2 ; Ahmed F3 ; Alkhazali HM4 ; Ambrosini A5 ; Ashina S6, 7 ; Baraldi C8 ; Bellotti A9 ; Brighina F10 ; Calabresi P11 ; Casillo F13 ; Cevoli S14 ; Cheng S15 ; Chiang CC16 Show All Authors
Authors
  1. Ornello R1
  2. Caponnetto V2
  3. Ahmed F3
  4. Alkhazali HM4
  5. Ambrosini A5
  6. Ashina S6, 7
  7. Baraldi C8
  8. Bellotti A9
  9. Brighina F10
  10. Calabresi P11
  11. Casillo F13
  12. Cevoli S14
  13. Cheng S15
  14. Chiang CC16
  15. Chiarugi A17
  16. Christensen RH4, 7
  17. Chu MK18
  18. Coppola G13
  19. Corbelli I9
  20. Crema S19
  21. De Icco R20, 21
  22. De Tommaso M22
  23. Di Lorenzo C13
  24. Di Stefano V10
  25. Diener HC23
  26. Ekizoglu E24
  27. Fallacara A25
  28. Favoni V14
  29. Garces KN26
  30. Geppetti P17, 27
  31. Goicochea MT19
  32. Granato A28
  33. Granella F29
  34. Guerzoni S8
  35. Ha WS30
  36. Hassan A31
  37. Hirata K32
  38. Hoffmann J33
  39. Hussler EM34
  40. Hussein M35
  41. Iannone LF17
  42. Jenkins B36
  43. Labastidaramirez A37
  44. Laporta A22
  45. Levin M39
  46. Lupica A10
  47. Mampreso E40
  48. Martinelli D20
  49. Monteith TS25
  50. Orologio I41
  51. Ozge A42
  52. Pan LLH43
  53. Panneerchelvam LL3
  54. Peres MFP44
  55. Souza MNP45
  56. Pozorosich P46
  57. Prudenzano MP25
  58. Quattrocchi S14
  59. Rainero I48
  60. Romanenko V49
  61. Romozzi M11
  62. Russo A41
  63. Sances G20
  64. Sarchielli P9
  65. Schwedt TJ50
  66. Silvestro M41
  67. Swerts DB51
  68. Tassorelli C20, 21
  69. Tessitore A41
  70. Togha M52, 53
  71. Vaghi G20, 21
  72. Wang SJ54, 55
  73. Ashina M4, 18
  74. Sacco S1

Source: Cephalalgia : an international journal of headache Published:2025


Abstract

We here present evidence-based guidelines for the pharmacological treatment of migraine. These guidelines, created by the Italian Society for the Study of Headache and the International Headache Society, aim to offer clear, actionable recommendations to healthcare professionals. They incorporate evidence-based recommendations from randomized controlled trials and expert-based opinions. The guidelines follow the Grading of Recommendations, Assessment, Development and Evaluation approach for assessing the quality of evidence. The guideline development involved a systematic review of literature across multiple databases, adherence to Cochrane review methods, and a structured framework for data extraction and interpretation. Although the guidelines provide a robust foundation for migraine treatment, they also highlight gaps in current research, such as the paucity of head-to-head drug comparisons and the need for long-term outcome studies. These guidelines serve as a resource to standardize migraine treatment and promote high-quality care across different healthcare settings.
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