Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Deep Brain Stimulation in a Rat Model of Post-Traumatic Stress Disorder Modifies Forebrain Neuronal Activity and Serum Corticosterone Publisher



Hashtjini MM1, 2 ; Jahromi GP2 ; Sadr SS1 ; Meftahi GH2 ; Hatef B2 ; Javidnazar D1
Authors

Source: Iranian Journal of Basic Medical Sciences Published:2018


Abstract

Objective(s): Post-traumatic stress disorder (PTSD), one of the most devastating kinds of anxiety disorders, is the consequence of a traumatic event followed by intense fear. In rats with contextual fear conditioning (CFC), a model of PTSD caused by CFC (electrical foot shock chamber), deep brain stimulation (DBS) alleviates CFC abnormalities. Materials and Methods: Forty Male Wistar rats (220–250 g) were divided into 5 groups (n=8) and underwent stereotactic surgery to implant electrodes in the right basolateral nucleus of the amygdala (BLn). After 7 days, some animals received a foot shock, followed by another 7-day treatment schedule (DBS treatment). Next, freezing behavior was measured as a predicted response in the absence of the foot shock (re-exposure time). Blood serum corticosterone levels and amygdala c-Fos protein expression were assessed using Enzyme-linked immunosorbent assay (ELISA) and Western blot, respectively. Furthermore, freezing behaviors by re-exposure time test and general anxiety by elevated plus-maze (EPM) were evaluated. Results: PTSD decreased serum corticosterone levels and increased both amygdala c-Fos expression and freezing behaviors. Therefore, DBS treatment significantly (P<0.001) enhanced serum corticosterone levels and could significantly (P<0.001) reduce both c-Fos protein expression and freezing behaviors’ duration. However, DBS treatment has no effect on the general anxiety in PTSD rats. Conclusion: We argue that these outcomes might demonstrate the mechanism of DBS treatment, a complete therapeutic strategy, in PTSD patients. © 2018, Mashhad University of Medical Sciences. All rights reserved.
Related Docs
View other Related Docs
1. Role of Basal Stress Hormones and Amygdala Dimensions in Stress Coping Strategies of Male Rhesus Monkeys in Response to a Hazard-Reward Conflict, Iranian Journal of Basic Medical Sciences (2017)
2. Saffron (Crocus Sativus) Aqueous Extract Reverses the Hypothalamus-Pituitary-Adrenal Axis Activity in Rat Model of Post-Traumatic Stress Disorder, Revista Brasileira de Farmacognosia (2019)
3. New Insights Into Contradictory Changes in Brain-Derived Neurotrophic Factor (Bdnf) in Rodent Models of Posttraumatic Stress Disorder (Ptsd), Neurochemical Research (2024)
Experts (# of related papers)
View all Related Experts
Esmail Riahi (2)
Shahin Akhondzadeh Basti (2)
Other Related Docs
4. Deep Brain Stimulation of the Lateral Hypothalamus Facilitates Extinction and Prevents Reinstatement of Morphine Place Preference in Rats, Neuromodulation (2021)
5. 5-Ht1a Receptor Blockade Targeting the Basolateral Amygdala Improved Stress-Induced Impairment of Memory Consolidation and Retrieval in Rats, Neuroscience (2015)
6. Peripheral Blood Levels of Brain-Derived Neurotrophic Factor in Patients With Posttraumatic Stress Disorder (Ptsd): A Systematic Review and Meta-Analysis, PLoS ONE (2020)
7. Effects of Left Prefrontal Transcranial Direct Current Stimulation on the Acquisition of Contextual and Cued Fear Memory, Iranian Journal of Basic Medical Sciences (2017)
8. Role of the Amygdala Gaba-A Receptors in Acpa-Induced Deficits During Conditioned Fear Learning, Brain Research Bulletin (2017)
9. Targeting Cis-P-Tau and Neuro-Related Gene Expression in Traumatic Brain Injury: Therapeutic Insights From Tc-Dapk6 Treatment in Mice, Molecular Biology Reports (2024)
10. Different Protocols of Rem Sleep Deprivation Led to Controversial Effects on Ocd- and Anxiety-Like Behaviors and Locomotor Activity in Fear Conditioning Male and Female Rats With Respect to Bdnf Expression Level, Pharmacology Biochemistry and Behavior (2025)
11. Modulation of Cannabinoid Signaling by Amygdala Α2-Adrenergic System in Fear Conditioning, Behavioural Brain Research (2016)
12. Anxiety and Hippocampal Neuronal Activity: Relationship and Potential Mechanisms, Cognitive# Affective and Behavioral Neuroscience (2022)
13. Role of the Basolateral Amygdala Dopamine Receptors in Arachidonylcyclopropylamide-Induced Fear Learning Deficits, Psychopharmacology (2016)
14. Sumatriptan Attenuates Fear-Learning Despair Induced by Social Isolation Stress in Mice: Mediating Role of Hypothalamic-Pituitary-Adrenal Axis, Psychoneuroendocrinology (2024)
15. Targeting Neuronal Nitric Oxide Synthase and the Nitrergic System in Post-Traumatic Stress Disorder, Psychopharmacology (2022)
16. The Fluctuations of Metabotropic Glutamate Receptor Subtype 5 (Mglur5) in the Amygdala in Fear Conditioning Model of Male Wistar Rats Following Sleep Deprivation, Reverse Circadian and Napping, Brain Research (2020)
17. Acute Physical and Psychological Stress Effects on Visceral Hypersensitivity in Male Rat: Role of Central Nucleus of the Amygdala; [Efeitos Agudos Do Estresse Fisico E Psicologico Na Hipersensibilidade Visceral Em Rato Macho: Papel Do Nucleo Central Da Amidala], Journal of Coloproctology (2017)
18. Synergistic Effects of Citicoline and Silymarin Nanomicelles in Restraint Stress-Exposed Mice, Behavioural Brain Research (2024)
19. Melatonin Attenuated the Behavioral Despair Induced by Acute Neurogenic Stress Through Blockade of N-Methyl D-Aspartate Receptors in Mice, Heliyon (2021)
20. Mesenchymal Stem Cells and Their Conditioned Medium As Potential Therapeutic Strategies in Managing Comorbid Anxiety in Rat Sepsis Induced by Cecal Ligation and Puncture, Iranian Journal of Basic Medical Sciences (2022)