Sulfamic Acid-Functionalized Hydroxyapatite-Encapsulated Γ-Fe2o3 Nanoparticles As a Magnetically Recoverable Catalyst for Synthesis of N-Fused Imidazole-Quinoline Conjugates Under Solvent-Free Conditions Publisher



Mouradzadegun A¹ ; Mamani L² ; Mahdavi M³ ; Rashid Z⁴ ; Shafiee A³ ; Foroumadi A³ ; Dianat S¹
Source: RSC Advances Published:2015

Abstract

Novel conjugated imidazo[1,2-a]pyridine and imidazo[2,1-b]thiazol-quinoline derivatives were synthesized through a one-pot condensation reaction of 2-chloro-3-formyl-quinoline, isocyanides and various amidines in the presence of catalytic amounts of sulfamic acid-functionalized γ-Fe2O3 nanoparticles encapsulated by hydroxyapatite (denoted as [γ-Fe2O3-HAp-(CH2)3-NHSO3H]) under solvent-free conditions. A series of N-fused 2-(2-chloro-quinolin-3-yl)-3-aminoimidazole derivatives were obtained in high to excellent yields using a mild and environmentally benign protocol by applying [γ-Fe2O3-HAp-(CH2)3-NHSO3H] as an efficient magnetically recoverable Bronsted acid catalyst. It is notable that the catalyst could be easily recovered and reused without any significant loss of its performance and activity. © The Royal Society of Chemistry.