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Comparison of Efficacy of Granisetron and Promethazine in Control of Hyperemesis Gravidarum Publisher



Aleyasin A1 ; Saffarieh E5 ; Torkamandi H2 ; Hanafi S2 ; Sadeghi F2 ; Mahdavi A1 ; Bahmaei F1 ; Javadi M3, 4
Authors

Source: Journal of Obstetrics and Gynecology of India Published:2016


Abstract

Purpose: Hyperemesis gravidarum is the third leading cause of hospitalization during pregnancy. 5-HT3-receptor antagonists are the most effective against chemotherapy-induced nausea and vomiting and radiation. This randomized study aimed to compare and evaluate the efficacies of granisetron and promethazine for controlling nausea and vomiting of pregnancy. Methods: The included patients were administered (oral and intravenous) granisetron and promethazine randomly. The patients were evaluated for nausea and vomiting by a senior gynecology resident blinded to designated drugs. Results: This study revealed that granisetron significantly decreased nausea and vomiting in pregnant women (pi¿½
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