Relationship Between Phosphatase and Tensin Homolog (Pten) Expression in High Grade Glioma and Histopathologic Findings Publisher



Hayati N¹ ; Tabriz HM¹ ; Nazar E¹ ; Gorji R²
Source: Romanian Journal of Neurology/ Revista Romana de Neurologie Published:2021

Abstract

Introduction. Malignant glioma is resistant brain tumor to treatment and considered by aggressiveness that fails success-ful resection. Molecular pathways including PTEN related with tumor behavior. Materials and methods. We studied the immunohistochemichal expression of PTEN in 32 brain surgical resection speci-mens with different histologic grades. All samples were from pathology department of Sina hospital in Tehran-Iran from 2020-2021. Results. From 32 patients, 21 (65.6%) had no PTEN staining. There was significant relationship between high age and no PTEN expression and average age with no PTEN staining was 54.05±14.01 years (P value: 0.044). There was significant relationship between necrosis in histopathologic evaluation with no PTEN staining (P value: 0.016). Also, there was no significant relationship between sex, tumor’s size, Tumor’s site, tumor’s grade, and primary or secondary type of tumor with PTEN staining (P value > 0.05). Conclusion. PTEN expression related to histopathologic features such as necrosis and age. PTEN can be introduced as an important prognostic indicator in high grade. © 2021, Editura Medicala. All rights reserved.