Update on Sars-Cov-2 Seroprevalence: Regional and Worldwide Publisher Pubmed



Rostami A¹ ; Sepidarkish M² ; Fazlzadeh A³ ; Mokdad AH⁴ ; Sattarnezhad A⁵ ; Esfandyari S⁶ ; Riahi SM⁷ ; Mollalo A⁸ ; Dooki ME⁹ ; Bayani M¹ ; Nazemipour M¹⁰ ; Mansournia MA¹¹ ; Hotez PJ¹² ; Gasser RB¹³
Source: Clinical Microbiology and Infection Published:2021

Abstract

Background: With limited vaccine supplies, an informed position on the status of SARS-CoV-2 infection in people can assist the prioritization of vaccine deployment. Objectives: We performed a systematic review and meta-analysis to estimate the global and regional SARS-CoV-2 seroprevalences around the world. Data sources: We systematically searched peer-reviewed databases (PubMed, Embase and Scopus), and preprint servers (medRxiv, bioRxiv and SSRN) for articles published between 1 January 2020 and 30 March 2021. Study eligibility criteria: Population-based studies reporting the SARS-CoV-2 seroprevalence in the general population were included. Participants: People of different age groups, occupations, educational levels, ethnic backgrounds and socio-economic status from the general population. Interventions: There were no interventions. Methods: We used the random-effects meta-analyses and empirical Bayesian method to estimate the pooled seroprevalence and conducted subgroup and meta-regression analyses to explore potential sources of heterogeneity as well as the relationship between seroprevalence and socio-demographics. Results: We identified 241 eligible studies involving 6.3 million individuals from 60 countries. The global pooled seroprevalence was 9.47% (95% CI 8.99–9.95%), although the heterogeneity among studies was significant (I2 = 99.9%). We estimated that ∼738 million people had been infected with SARS-CoV-2 (as of December 2020). Highest and lowest seroprevalences were recorded in Central and Southern Asia (22.91%, 19.11–26.72%) and Eastern and South-eastern Asia (1.62%, 1.31–1.95%), respectively. Seroprevalence estimates were higher in males, persons aged 20–50 years, in minority ethnic groups living in countries or regions with low income and human development indices. Conclusions: The present study indicates that the majority of the world's human population was still highly susceptible to SARS-CoV-2 infection in mid-2021, emphasizing the need for vaccine deployment to vulnerable groups of people, particularly in developing countries, and for the implementation of enhanced preventive measures until ‘herd immunity’ to SARS-CoV-2 has developed. © 2021 European Society of Clinical Microbiology and Infectious Diseases