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Evaluation of Structural, Mechanical, and Cellular Behavior of Electrospun Poly-3-Hydroxybutyrate Scaffolds Loaded With Glucosamine Sulfate to Develop Cartilage Tissue Engineering Publisher



Shahali Z1 ; Karbasi S2 ; Avadi MR1 ; Semnani D3 ; Naghash Zargar E3 ; Hashemibeni B4
Authors

Source: International Journal of Polymeric Materials and Polymeric Biomaterials Published:2017


Abstract

Considering the role of glucosamine sulfate (GS) in the biosynthetic pathways of chondrocytes, an attempt was made to design an electrospun poly-3-hydroxybutyrate (PHB) scaffold loaded with GS to develop cartilage tissue engineering. The study was initiated using the optimal electrospun scaffold conditions for the synthesis of PHB/GS. The resulting scaffolds have shown excellent pore architectures and mechanical behavior compared to pure PHB. UV spectrophotometric analysis, for the evaluation of the GS release behavior, showed zero-order kinetics release. In vitro results indicated excellent cell viability, cell adhesion, and cell penetration of PHB/GS scaffolds compared to pure PHB. © 2017 Taylor & Francis.
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