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The Synthesis and Characterization of Double Nanoemulsion for Targeted Co-Delivery of 5-Fluorouracil and Curcumin Using Ph-Sensitive Agarose/Chitosan Nanocarrier Publisher



Pourmadadi M1 ; Ahmadi M1 ; Abdouss M2 ; Yazdian F3 ; Rashedi H1 ; Navaeinigjeh M4, 5 ; Hesari Y1
Authors

Source: Journal of Drug Delivery Science and Technology Published:2022


Abstract

Due to the dangerous side effects of chemotherapy, advanced methods for curing cancer, such as drug delivery, have attracted much attention because of their high efficacies. Using a green synthesizing method, we prepared a double nano-emulsion agarose/chitosan nanocomposite as the carrier of this work to adjust stability and hydrogel releasing. Curcumin, 5-fluorouracil, and curcumin/5-fluorouracil were loaded into the nano-carrier, and the synthesized systems were characterized by XRD, FESEM, FTIR, DLS, and zeta potential analysis. Loading efficacy and entrapment efficacy of curcumin in the agarose/chitosan nanocomposite were 85.6% and 79.2%, respectively. Drug release profiles proved the pH sensitivity of the nanocomposite by providing a 24–44% difference in drug cumulative release rate between the tumor-simulated and the normal cell-simulated buffers. Also, MTT and the flow cytometry analysis showed the biocompatibility of the carrier and the effect of using both drugs, as a co-delivery system, on cytotoxicity against the MCF-7 cells. These results demonstrate the potential of the chitosan/agarose@curcumin/5-fluorouracil to be a candidate for the targeted treatment of cancer cells. © 2021 Elsevier B.V.
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