Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Association Between Micrornas and Chemoresistance in Pancreatic Cancer: Current Knowledge, New Insights, and Forthcoming Perspectives Publisher Pubmed



Rahnama N1 ; Jahangir M2 ; Alesaeid S3 ; Kahrizi MS4 ; Adili A5, 6 ; Mohammed RN7, 8 ; Aslaminabad R9 ; Akbari M9 ; Ozgonul AM10
Authors

Source: Pathology Research and Practice Published:2022


Abstract

Pancreatic duct adenocarcinoma, commonly known as pancreatic cancer (PC), is a cancer-related cause of death due to delayed diagnosis, metastasis, and drug resistance. Patients with PC suffer from incorrect responses to chemotherapy due to inherent and acquired chemical resistance. Numerous studies have shown the mechanism of the effect of chemoresistance on PC, such as genetic and epigenetic changes or the elucidation of signaling pathways. In this regard, microRNAs (miRNAs) have been identified as essential modulators of gene expression in various cellular functions, including chemoresistance. Thus, identifying the underlying link between microRNAs and PC chemoresistance helps determine the exact pathogenesis of PC. This study aims to classify miRNAs and signaling pathways related to PC chemoresistance, suggesting new therapeutic approaches to overcome PC chemoresistance. © 2022
Related Docs
View other Related Docs
1. Mir-608 Regulating the Expression of Ribonucleotide Reductase M1 and Cytidine Deaminase Is Repressed Through Induced Gemcitabine Chemoresistance in Pancreatic Cancer Cells, Cancer Chemotherapy and Pharmacology (2017)
2. The Critical Role of Circular Rnas in Drug Resistance in Gastrointestinal Cancers, Medical Oncology (2023)
3. The Role of Oncomirs in the Pathogenesis and Treatment of Breast Cancer, Biomedicine and Pharmacotherapy (2016)
Experts (# of related papers)
View all Related Experts
Hamid Reza Mirzaei (3)
Habibollah Mahmoodzadeh (2)
Other Related Docs
4. Diagnostic and Prognostic Accuracy of Mirnas in Pancreatic Cancer: A Systematic Review and Meta-Analysis, Journal of Cellular and Molecular Medicine (2025)
5. A Comprehensive Survey Into the Role of Exosomes in Pancreatic Cancer; From the Origin of Cancer to the Progress and Possibility of Diagnosis and Treatment, Pathology Research and Practice (2023)
6. Microrna-155 and Its Exosomal Form: Small Pieces in the Gastrointestinal Cancers Puzzle, Cell Biology and Toxicology (2024)
7. Gastrointestinal Cancer Drug Resistance: The Role of Exosomal Mirnas, Molecular Biology Reports (2022)
8. Exosomes and Micrornas in Biomedical Science, Synthesis Lectures on Biomedical Engineering (2022)
9. Circular Rnas and Gastrointestinal Cancers: Epigenetic Regulators With a Prognostic and Therapeutic Role, Critical Reviews in Oncology/Hematology (2020)
10. Non-Coding Rnas and Glioblastoma: Insight Into Their Roles in Metastasis, Molecular Therapy Oncolytics (2022)
11. Non-Coding Rnas in Leukemia Drug Resistance: New Perspectives on Molecular Mechanisms and Signaling Pathways, Annals of Hematology (2024)
12. Up-Regulation of Kiss1 As a Novel Target of Let-7I in Melanoma Serves As a Potential Suppressor of Migration and Proliferation in Vitro, Journal of Cellular and Molecular Medicine (2021)
13. Exosomal Micrornas in Regulation of Tumor Cells Resistance to Apoptosis, Biochemistry and Biophysics Reports (2024)
14. Mir-377 Reverses Cancerous Phenotypes of Pancreatic Cells Via Suppressing Dnmt1 and Demethylating Tumor Suppressor Genes, Epigenomics (2017)
15. Hsa-Mir-3529-5P Through F2rl3 Regulation As an Enhancer of Sensitivity to Cisplatin, Indian Journal of Clinical Biochemistry (2024)
16. Microrna-Induced Drug Resistance in Gastric Cancer, Biomedicine and Pharmacotherapy (2015)
17. Micrornas As Potential Diagnostic and Prognostic Biomarkers in Melanoma, European Journal of Cancer (2016)
18. The Landscape of Exosomal Non-Coding Rnas in Breast Cancer Drug Resistance, Focusing on Underlying Molecular Mechanisms, Frontiers in Pharmacology (2023)
19. Small Molecules With Huge Impacts: The Role of Mirna-Regulated Pi3k Pathway in Human Malignancies, Molecular Biology Reports (2021)
20. Microrna: A New Player in Response to Therapy for Colorectal Cancer, Journal of Cellular Physiology (2019)