Diagnostic Performance of Contrast-Enhanced Ultrasound in Traumatic Solid Organ Injuries in Children: A Systematic Review and Meta-Analysis Publisher Pubmed



Jannatdoust P¹ ; Valizadeh P¹ ; Hassankhani A^{2, 3} ; Amoukhteh M^{2, 3} ; Ghadimi DJ⁴ ; Heidariforoozan M^{5, 6} ; Sabeghi P² ; Adli P⁷ ; Johnston JH⁸ ; Vasavada PS⁹ ; Gholamrezanezhad A²
Source: Pediatric Radiology Published:2025

Abstract

Background: Blunt abdominal trauma (BAT) is a significant contributor to pediatric mortality, often causing liver and spleen injuries. Contrast-enhanced computed tomography (CT), the gold standard for diagnosing solid organ injury, poses radiation risks to children. Contrast-enhanced ultrasound (CEUS) may be a promising alternative imaging modality. Objectives: To evaluate the diagnostic utility of CEUS for detecting solid organ injuries following BAT in the pediatric population. Methods: A systematic review and meta-analysis were conducted through a thorough literature search in PubMed, Scopus, Web of Science, and Embase databases up to October 1, 2023. Diagnostic accuracy metrics were aggregated using a bivariate model, and subgroup meta-analysis compared CEUS accuracy across various organs. Results: Meta-analysis from four studies, including 364 pediatric patients, revealed a pooled sensitivity of 88.5% (95%CI 82.5–92.6%) and specificity of 98.5% (95%CI 94.9–99.6%), with an area under the curve of 96% (95%CI 88 – 99%). Splenic injuries showed higher sensitivity than liver injuries (P-value < 0.01), while kidney assessments demonstrated higher specificity (P-value < 0.05). Conclusion: This study highlights the diagnostic potential of CEUS for pediatric solid organ injuries caused by BAT. Further large-scale studies are needed due to the limited number and sample size of the included studies. © The Author(s) 2024.