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Early Onset Inflammatory Bowel Disease: Manifestations, Genetics and Diagnosis Publisher Pubmed



Moazzami B1, 2 ; Moazzami K3, 4 ; Rezaei N1, 5, 6
Authors

Source: Turkish Journal of Pediatrics Published:2019


Abstract

Moazzami B, Moazzami K, Rezaei N. Early onset inflammatory bowel disease: manifestations, genetics and diagnosis. Turk J Pediatr 2019; 61: 637-647. Crohn’s disease and ulcerative colitis are immunologically mediated chronic inflammatory conditions, collectively referred to as inflammatory bowel diseases (IBD). While most studies have described the condition in the adult population, recent evidences suggest that IBD in children may represent an etiologically distinct disease from the adult onset IBD. Since a significant proportion of patients diagnosed with IBD demonstrate their clinical manifestations during childhood, knowledge about the disease progression, severity and diagnosis in this particular patient population is crucial. Therefore, in the present study, the clinical manifestations, recent advancements in the genetics of early onset IBD and the clinical approach to diagnoses of IBD in children are described. © 2019, Turkish Journal of Pediatrics. All rights reserved.
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