Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Synthesis and Evaluation of Antiviral Activities of Novel Sonochemical Silver Nanorods Against Hiv and Hsv Viruses Publisher



Etemadzade M1 ; Ghamarypour A2 ; Zabihollahi R6 ; Shabbak G1 ; Shirazi M2 ; Sahebjamee H3 ; Vaziri AZ4 ; Assadi A4 ; Ardestani MS4 ; Shandiz SAS5 ; Aghasadeghi MR6
Authors

Source: Asian Pacific Journal of Tropical Disease Published:2016


Abstract

Objective To evaluate the effect of novel sonochemical silver nanorods on HIV and herpes simplex virus type 1 (HSV-1) viruses in human cervical cancer HeLa cells. Methods The formation of silver nanorods conjugated with sodium 2-mercaptoethane sulfonate (Ag-MES) was characterized by scanning electron microscopy, Fourier transform infrared spectroscopy and thermal gravimetric analysis. The antiviral activity of this Ag-MES was examined against HIV and HSV-1 virus replication. Results The characterizations of Ag-MES and physiochemical structure were determined by scanning electron microscopy, Fourier transform infrared spectroscopy and thermal gravimetric analysis. Approximately entire viral replication was inhibited by Ag-MES at 10 μmol/mL concentration. About 90% of HSV virions failed to replicate in the present of this concentration of nanorods. However, HIV showed more sensitivity to Ag-MES than HSV-1. Conclusions According to the obtained data, the synthesized sonochemical silver nanorod in this study is a promising candidate for further drug discovery investigation. © 2016 Asian Pacific Tropical Medicine Press
Other Related Docs
6. A Promising Treatment for Hiv-1 Using Biosynthesis of Metal Nanoparticles, Journal of Industrial and Engineering Chemistry (2022)
10. Nanomaterials and Optical Diagnosis of Hiv, Artificial Cells# Nanomedicine and Biotechnology (2016)