Neuroscience-Informed Psychoeducation (Nipe): How Brain Awareness Supports Brain Recovery Publisher

Summary: Could brain-focused education aid recovery? A review argues neuroscience-informed psychoeducation may support insight and adherence, but clinical benefits need testing. #Psychoeducation #Neuroscience

Rezapour T ; Berry J ; Cullum C M ; Elahi B ; Deville D ; Elbanna I ; Elsabbahy M ; Farokhnia M ; Haque N ; Jin J ; Juruena M F ; Kerr K L ; Khojasteh Zonoozi A ; Lewandowska A J Show All Authors
Source: Progress in Brain Research Published:2026

Abstract

Over the past two decades, Neuroscience-Informed Psychoeducation (NIPE) has gradually evolved and become integrated into various therapy modules for psychiatric and neurological disorders. Although NIPE shares certain features with conventional psychoeducation, it is distinguished by key content and structure-related elements. Its content centers on brain-based explanations of the mechanisms and symptoms underlying psychiatric and neurological disorders, as well as the neural processes associated with treatment response, remission, and recovery. NIPE promotes self-awareness and insight and may contribute to motivation for treatment and treatment adherence. It also informs patients, caregivers, and communities how to play an active role in the prevention, treatment, and recovery process based on this mechanistic understanding. Structurally, NIPE is designed to align with how the brain learns and adapts, improving the learning experience to promote more enduring outcomes. By clarifying the processes and goals of brain recovery, increasing self-awareness and self-efficacy, and supporting adherence to prescribed treatments, NIPE may enhance motivation and retention, and facilitate recovery while reducing shame and stigma. This paper provides an introductory overview of NIPE including its definitions and terminology, the current evidence base, clinical implications, and directions for future development. Copyright © 2026. Published by Elsevier B.V.