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Beyond Car-T: The Rise of Car-Nk/T Cells for Haematological Cancer Publisher Pubmed



Noorafrooz M ; Gale RP ; Dashtkoohi M
Authors

Source: Acta Haematologica Published:2025


Abstract

Background: Chimeric antigen receptor (CAR)-natural killer (NK)/T-cells offer a new approach in immune therapy of haematological cancers. NK/T-cells bridge innate and adaptive immunity with strong anti-cancer effects. Unlike allogeneic CAR-T-cells, CAR-NK/T-cells do not require TCR genetic deletion to prevent major MHC recognition, have a lower risk of graft-versus-host disease, and can be used universally. Summary: Pre-clinical studies report CAR-NK/T-cells effectively target antigens such as CD19 and B-cell maturation antigen in B-cell lymphomas and plasma cell myeloma. Compared with CAR-T-cells, CAR-NK/T-cells have faster immune responses, more cytotoxicity and better safety. Recent innovations increase efficacy of CAR-NK/T-cell therapies. Early clinical trials report promising safety and efficacy. Although still in the early phases of development, advances in NK/T-cell therapy are overcoming prior challenges. Key Messages: CAR-NK/T-cells may prove a safer, more flexible form of cell therapy of haematological cancers. © 2025 Elsevier B.V., All rights reserved.
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