Association Between Human Herpesvirus-6 and Primary Brain Tumors: A Systematic Review and Meta-Analysis Publisher



Ghorbani S¹ ; Letafati A² ; Khatami A¹ ; Farzi R³ ; Shabani S⁴ ; Moradi P⁵ ; Tambrchi V¹ ; Saadati H⁶ ; Papizadeh S⁷ ; Rad MV⁸ ; Tabatabaei R⁹ ; Bahadory S¹⁰ ; Tavakoli A^{1, 11} ; Bokharaeisalim F¹ Show All Authors
Source: Future Virology Published:2022

Abstract

Aim: The present study aimed to find out the prevalence and any possible association between human herpesvirus (HHV-6) and primary brain tumors. Materials & methods: The systematic literature search was performed by finding related articles from major databases. Analysis was performed by comprehensive meta-analysis software. Results: A total of 13 (25 datasets) articles were included in the study, seven (15 datasets) of which were case/control and the rest (10 datasets) were cross-sectional studies. The pooled prevalence of HHV-6 among primary brain cancer patients was 29% (95% CI: 24-33%; I2 = 97.89%). An association was found between HHV-6 and primary brain cancer (summary odds ratio: 3.77% [95% CI: 2.59-5.49%; I2 = 19.0%]). Conclusion: Our analysis demonstrated that HHV-6 is associated with primary brain cancer. Reactivation of the virus could be triggered by the tumor, therefore, we cannot be certain that the virus appeared before the cancer development. © 2022 Future Medicine Ltd.