The Effects of Ca1 5Ht4 Receptors in Mk801-Induced Amnesia and Hyperlocomotion Publisher Pubmed



Nasehi M¹ ; Tabatabaie M² ; Khakpai F² ; Zarrindast MR^{1, 2, 3, 4}
Source: Neuroscience Letters Published:2015

Abstract

In this study, the effects of 5-HT4 receptors of the CA1 on MK801-induced amnesia and hyperlocomotion were examined. One-trial step-down method was used to assess memory retention and then, the hole-board method to assess exploratory behaviors. The results showed that post-training intra-CA1 administration of RS67333 (62.5 and 625. ng/mouse) and RS23597 (1 and 10. ng/mouse) decreased memory consolidation, but it did not alter head-dip counts, head-dip latency and locomotor activity. Similarly, MK801 (0.5 and 1. μg/mouse) decreased memory consolidation, but had no effect on head-dip counts and head-dip latency. Interestingly, it increased locomotor activity. The results also showed that post-training intra-CA1 injection of a sub-threshold dose of RS67333 (6.25. ng/mouse) or RS23597 (0.1. ng/mouse) could heighten MK801 induced amnesia and decrease locomotor activity, but it did not alter head-dip counts and head-dip latency. In conclusion, our findings suggest that the CA1 5-HT4 receptors are involved in MK801-induced amnesia and hyperlocomotion. © 2014.