Gene Therapy: A Promising Approach for Breast Cancer Treatment Publisher Pubmed



Dastjerd NT¹ ; Valibeik A² ; Rahimi Monfared S² ; Goodarzi G^{3, 4} ; Moradi Sarabi M⁵ ; Hajabdollahi F⁶ ; Maniati M⁷ ; Amri J^{3, 4} ; Samavarchi Tehrani S^{3, 4}
Source: Cell Biochemistry and Function Published:2022

Abstract

Breast cancer (BC) is the most prevalent malignancy and the second leading cause of death among women worldwide that is caused by numerous genetic and environmental factors. Hence, effective treatment for this type of cancer requires new therapeutic approaches. The traditional methods for treating this cancer have side effects, therefore so much research have been performed in last decade to find new methods to alleviate these problems. The study of the molecular basis of breast cancer has led to the introduction of gene therapy as an effective therapeutic approach for this cancer. Gene therapy involves sending genetic material through a vector into target cells, which is followed by a correction, addition, or suppression of the gene. In this technique, it is necessary to target tumour cells without affecting normal cells. In addition, clinical trial studies have shown that this approach is less toxic than traditional therapies. This study will review various aspects of breast cancer, gene therapy strategies, limitations, challenges and recent studies in this area. © 2021 John Wiley & Sons Ltd