Curcumin and Targeting of Molecular and Metabolic Pathways in Multiple Sclerosis Publisher Pubmed



Yazdani Y¹ ; Zamani ARN² ; Majidi Z³ ; Sharafkandi N⁴ ; Alizadeh S⁵ ; Mofrad AME⁶ ; Valizadeh A⁷ ; Idari G⁸ ; Radvar AD⁹ ; Safaie N¹⁰ ; Faridvand Y^{10, 11}
Source: Cell Biochemistry and Function Published:2023

Abstract

Multiple sclerosis (MS) is a life-threading disease that poses a great threat to the human being lifestyle. Having said extensive research in the realm of underlying mechanisms and treatment procedures, no definite remedy has been found. Over the past decades, many medicines have been disclosed to alleviate the symptoms and marking of MS. Meanwhile, the substantial efficacy of herbal medicines including curcumin must be underscored. Accumulated documents demonstrated the fundamental role of curcumin in the induction of the various signaling pathways. According to evidence, curcumin can play a role in mitochondrial dysfunction and apoptosis, autophagy, and mitophagy. Also, by targeting the signaling pathways AMPK, PGC-1α/PPARγ, and PI3K/Akt/mTOR, curcumin interferes with the metabolism of MS. The anti-inflammatory, antioxidant, and immune regulatory effects of this herbal compound are involved in its effectiveness against MS. Thus, the present review indicates the molecular and metabolic pathways associated with curcumin's various pharmacological actions on MS, as well as setting into context the many investigations that have noted curcumin-mediated regulatory effects in MS. © 2023 John Wiley & Sons Ltd.