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Synthesis, Evaluation, and Molecular Docking Studies of Aryl Urea-Triazole-Based Derivatives As Anti-Urease Agents Publisher Pubmed



Moghimi S1 ; Goligarmroodi F2 ; Allahyaridevin M3 ; Pilali H2 ; Hassanzadeh M1 ; Mahernia S1 ; Mahdavi M4 ; Firoozpour L2 ; Amanlou M1, 5 ; Foroumadi A1, 5
Authors

Source: Archiv der Pharmazie Published:2018


Abstract

Considering the importance of urease inhibitors in the treatment of ureolytic bacterial infections, in this work, the synthesis of novel, aryl urea-triazole-based derivatives as effective urease inhibitors is described. Dichloro-substituted derivative 4o, with IC50 = 22.81 ± 0.05 μM, is found to be the most potent urease inhibitor, determined by Berthelot colorimetric assay. Docking studies were also carried out for compound 4o to confirm the effective interactions with the urease active site. © 2018 Deutsche Pharmazeutische Gesellschaft
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