Engineering the Niche for Hair Regeneration — a Critical Review Publisher Pubmed



Nilforoushzadeh MA¹ ; Zare M¹ ; Zarrintaj P² ; Alizadeh E³ ; Taghiabadi E^{1, 4} ; Heidarikharaji M¹ ; Amirkhani MA¹ ; Saeb MR⁵ ; Mozafari M^{6, 7, 8}
Source: Nanomedicine: Nanotechnology# Biology# and Medicine Published:2019

Abstract

Recent progress in hair follicle regeneration and alopecia treatment necessitates revisiting the concepts and approaches. In this sense, there is a need for shedding light on the clinical and surgical therapies benefitting from nanobiomedicine. From this perspective, this review attempts to recognize requirements upon which new hair therapies are grounded; to underline shortcomings and opportunities associated with recent advanced strategies for hair regeneration; and most critically to look over hair regeneration from nanomaterials and pluripotent stem cell standpoint. It is noteworthy that nanotechnology is able to illuminate a novel path for reprogramming cells and controlled differentiation to achieve the desired performance. Undoubtedly, this strategy needs further advancement and a lot of critical questions have yet to be answered. Herein, we introduce the salient features, the hurdles that must be overcome, the hopes, and practical constraints to engineer stem cell niches for hair follicle regeneration. © 2018 Elsevier Inc.