Natural Flavonoids for the Prevention of Colon Cancer: A Comprehensive Review of Preclinical and Clinical Studies Publisher Pubmed



Afshari K¹ ; Haddadi NS¹ ; Hajmirzaian A¹ ; Farzaei MH^{2, 3} ; Rohani MM¹ ; Akramian F⁴ ; Naseri R¹ ; Sureda A^{5, 6} ; Ghanaatian N⁴ ; Abdolghaffari AH^{2, 7, 8, 9}
Source: Journal of Cellular Physiology Published:2019

Abstract

Flavonoids comprise a group of natural polyphenols consisting of more than 5,000 subtypes mostly existing in fruits and vegetables. Flavonoids consumption could potentially attenuate the incidence and recurrence risk of colorectal cancers through their antiperoxidative, antioxidant, and anti-inflammatory effects. In addition, these compounds regulate the mitochondrial function, balance the bacterial flora and promote the apoptosis process in cancerous cells. However, some previous data failed to show the effectiveness of flavonoids in reducing the risk of colorectal cancer. In this study, we have reviewed the efficacy of different flavonoids subtypes on the risk of colon cancer and molecular mechanisms involved in this process in both clinical and animal studies. In addition, we tried to elucidate the potential synergy between these compounds and current colorectal cancer treatments. © 2019 Wiley Periodicals, Inc.