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Ph-Responsive Polymer in a Core–Shell Magnetic Structure As an Efficient Carrier for Delivery of Doxorubicin to Tumor Cells Publisher



Zaaeri F1 ; Khoobi M2, 3 ; Rouini M1 ; Akbari Javar H1, 2
Authors

Source: International Journal of Polymeric Materials and Polymeric Biomaterials Published:2018


Abstract

A pH-responsive polymer derived from polyethyleneimine with zwitterionic function was used as a shell around super paramagnetic iron oxide nanoparticles (SPIONs), to introduce an efficient drug carrier for cancer drug delivery and imaging. Core–shell magnetic Fe3O4@FA-PEI-SUC (SUC: Succinate conjugated) nanoparticles were attained and characterized. Right chemical attachments, 61.34% modification of primary amino groups of poly(ethyleneimine) (PEI) in PEI–SUC, spherical shape, core–shell structure, crystal structure of SPIONs, 18.23% polymer coating of NPs, 8% decrease in magnetization following polymer coating around SPIONs, doxorubicin loading efficiency 85.19%, two times more released amount in acidic pH, and proper toxicity results were obtained by different analysis methods. © 2017, © 2017 Taylor & Francis.
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