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Therapy of Endocrine Disease: Islet Transplantation for Type 1 Diabetes: So Close and yet so Far Away Publisher Pubmed



Khosravimaharlooei M1, 7 ; Hajizadehsaffar E1 ; Tahamtani Y1 ; Basiri M1 ; Montazeri L1 ; Khalooghi K1 ; Ashtiani MK1 ; Farrokhi A1, 7 ; Aghdami N2 ; Hashemi Nejad AS1 ; Larijani MB3 ; De Leu N4 ; Heimberg H4 ; Luo X5 Show All Authors
Authors
  1. Khosravimaharlooei M1, 7
  2. Hajizadehsaffar E1
  3. Tahamtani Y1
  4. Basiri M1
  5. Montazeri L1
  6. Khalooghi K1
  7. Ashtiani MK1
  8. Farrokhi A1, 7
  9. Aghdami N2
  10. Hashemi Nejad AS1
  11. Larijani MB3
  12. De Leu N4
  13. Heimberg H4
  14. Luo X5
  15. Baharvand H1, 6

Source: European Journal of Endocrinology Published:2015


Abstract

Over the past decades, tremendous efforts have been made to establish pancreatic islet transplantation as a standard therapy for type 1 diabetes. Recent advances in islet transplantation have resulted in steady improvements in the 5-year insulin independence rates for diabetic patients. Here we review the key challenges encountered in the islet transplantation field which include islet source limitation, sub-optimal engraftment of islets, lack of oxygen and blood supply for transplanted islets, and immune rejection of islets. Additionally, we discuss possible solutions for these challenges. © 2015 European Society of Endocrinology.
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