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Long Non-Coding Rnas (Lncrnas); Roles in Tumorigenesis and Potentials As Biomarkers in Cancer Diagnosis Publisher Pubmed



Najafi S1 ; Khatami SH2 ; Khorsand M3 ; Jamali Z4 ; Shabaninejad Z5 ; Moazamfard M6 ; Majidpoor J7 ; Aghaei Zarch SM8 ; Movahedpour A6
Authors

Source: Experimental Cell Research Published:2022


Abstract

New research has indicated that long non-coding RNAs (lncRNAs) play critical roles in a broad range of biological processes, including the pathogenesis of many complex human diseases, including cancer. The detailed regulation mechanisms of many lncRNAs in cancer initiation and progression have yet to be discovered, even though a few of lncRNAs’ functions in cancer have been characterized. In the present study, we summarize recent advances in the mechanisms and functions of lncRNAs in cancer. We focused on the roles of newly-identified lncRNAs as oncogenes and tumor suppressors, as well as the potential pathways these molecules could play. The paper also discusses their potential uses as biomarkers for the diagnosis and prognosis of cancer. © 2022 Elsevier Inc.
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