Alterations in Choroidal Vascular Parameters Following Panretinal Photocoagulation Using Enhanced-Depth Imaging Optical Coherence Tomography in Diabetic Retinopathy Publisher Pubmed



Mirshahi A¹ ; Fadakar K¹ ; Mirshahi R² ; Khalili Pour E¹ ; Ebrahimiadib N¹ ; Ghassemi F¹ ; Khojasteh H¹ ; Bazvand F¹ ; Ghods S¹ ; Riaziesfahani H¹ ; Faghihi H¹
Source: Graefe's Archive for Clinical and Experimental Ophthalmology Published:2022

Abstract

Purpose: To investigate the alteration of choroid in patients with very severe non-proliferative diabetic retinopathy (NPDR) or early proliferative diabetic retinopathy (PDR) following panretinal photocoagulation (PRP). Methods: Thirty-nine eyes of 21 patients with very severe non-proliferative diabetic retinopathy (NPDR) (19 eyes) and early proliferative diabetic retinopathy (PDR) (20 eyes) were recruited. Enhanced-depth imaging optical coherence tomography at baseline, 1, and 6 months after PRP was employed to measure choroidal parameters including total choroidal area (TCA) and choroidal vascular index (CVI). Results: In eyes with very severe NPDR, subfoveal TCA decreased non-significantly at month 1, which increased significantly at month 6 (539 ± 131µm2, 502 ± 134µm2, and 598 ± 168µm2 at baseline and months 1 and 6, respectively; P = 0.003). Subfoveal CVI increased at month 1 and then decreased at month 6 (68.25 ± 3.05, 69.74 ± 3.62, and 67.84 ± 1.77 at baseline and months 1 and 6, respectively; P < 0.001). A reverse pattern occurred in eyes with early PDR, a non-significant increase in TCA at month 1 followed by a decrease at month 6 (497 ± 95µm2, 514 ± 133µm2, and 425 ± 95µm2 at baseline and months 1 and 6, respectively; P = 0.011). CVI decreased at month 1 and remained relatively stable at month 6 (69.34 ± 3.11, 68.33 ± 3.41, and 68.50 ± 5.04 at baseline, and months 1 and 6, respectively; P = 0.023). Alteration of choroidal thickness was not statistically significant in both groups. Conclusion: Eyes with very severe NPDR and early PDR exhibit a reverse pattern regarding choroidal indices after PRP. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.