Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
The Effects of Curcumin Supplementation on Biomarkers of Inflammation, Oxidative Stress, and Endothelial Function: A Meta-Analysis of Meta-Analyses Publisher Pubmed



Kavyani Z1 ; Najafi K2 ; Naghsh N3 ; Karvane HB4 ; Musazadeh V5, 6
Authors

Source: Prostaglandins and Other Lipid Mediators Published:2024


Abstract

Numerous interventional studies have revealed the beneficial impact of curcumin supplementation on inflammation, oxidative stress, and endothelial function biomarkers, but the findings are still inconsistent. Thus, this study was conducted to investigate the effects of curcumin supplementation on inflammation, oxidative stress, and endothelial function biomarkers. A meta-analyses of randomized clinical trials was performed by searching PubMed, Embase, Scopus, and Web of Science up to March 31, 2024. Pooled estimates of 21 meta-analyses revealed that curcumin significantly reduced CRP (weighted mean difference (WMD) = −0.87; 95 % CI: - 1.14, - 0.59, P< 0.001), tumor-necrosis factor-alpha (TNF-α) (WMD = −2.72; 95 % CI: −4.05, −1.38; P< 0.001), interleukin-6 (IL-6) (WMD = −0.97, 95 % CI: −1.40, −0.54; P< 0.001), malondialdehyde (MDA) (Effect size (ES) = −0.81; 95 % CI: −1.39, −0.23, P = 0.006) and pulse wave velocity (PWV) (WMD = −45.60; 95 % CI: −88.16, −3.04, P = 0.036), and increased flow-mediated dilation (FMD) (WMD = 1.64, 95 % CI: 1.06, 2.22, P < 0.001), catalase (CAT) (WMD = 10.26; 95 % CI: 0.92, 19.61, P= 0.03), glutathione peroxidase (GPx) (WMD = 8.90; 95 % CI: 6.62, 11.19, P <0.001), and superoxide dismutase (SOD) levels (WMD = 20.51; 95 % CI: 7.35, 33.67, P= 0.002 and SMD = 0.82; 95 % CI: 0.27, 1.38, P= 0.004). However, curcumin did not significantly change total antioxidant capacity (TAC) (ES = 0.29; 95 % CI: −0.09, 0.66, P= 0.059). These results suggest that curcumin has a beneficial effect on CRP, IL-6, TNF-α, SOD, GPx, CAT, MDA, PWV, and FMD levels and may be an effective adjunctive therapy for improving inflammation, oxidative stress, and endothelial function. Registration number: PROSPERO, CRD42024539018. © 2024 Elsevier Inc.
Related Docs
View other Related Docs
1. Effects of Curcumin Supplementation on Inflammatory Biomarkers in Patients With Rheumatoid Arthritis and Ulcerative Colitis: A Systematic Review and Meta-Analysis, Complementary Therapies in Medicine (2021)
2. Effect of Curcumin on Proinflammatory Cytokines: A Meta-Analysis of Randomized Controlled Trials, Cytokine (2021)
3. Nano-Curcumin Therapy, a Promising Method in Modulating Inflammatory Cytokines in Covid-19 Patients, International Immunopharmacology (2020)
Experts (# of related papers)
View all Related Experts
Mohammad Javad Hosseinzadeh Attar (2)
Atabak Najafi (1)
Other Related Docs
4. Effect of Curcumin on C-Reactive Protein As a Biomarker of Systemic Inflammation: An Updated Meta-Analysis of Randomized Controlled Trials, Phytotherapy Research (2022)
5. Effects of Curcuminoids on Inflammatory and Oxidative Stress Biomarkers and Clinical Outcomes in Critically Ill Patients: A Randomized Double-Blind Placebo-Controlled Trial, Phytotherapy Research (2021)
6. The Effect of Curcumin/Turmeric on Blood Pressure Modulation: A Systematic Review and Meta-Analysis, Pharmacological Research (2019)
7. Nano-Curcumin Improves Glucose Indices, Lipids, Inflammation, and Nesfatin in Overweight and Obese Patients With Non-Alcoholic Fatty Liver Disease (Nafld): A Double-Blind Randomized Placebo-Controlled Clinical Trial, Nutrition and Metabolism (2019)
8. Longevity and Anti-Aging Effects of Curcumin Supplementation, GeroScience (2024)
9. Impact of Curcumin Supplementation on Radiation Dermatitis Severity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Asian Pacific Journal of Cancer Prevention (2023)
10. Nano-Curcumin Supplementation in Critically Ill Patients With Sepsis: A Randomized Clinical Trial Investigating the Inflammatory Biomarkers, Oxidative Stress Indices, Endothelial Function, Clinical Outcomes and Nutritional Status, Food and Function (2022)
11. Molecular Mechanisms of Curcumin in Neuroinflammatory Disorders: A Mini Review of Current Evidences, Endocrine# Metabolic and Immune Disorders - Drug Targets (2019)
12. Curcuminoids Modify Lipid Profile in Type 2 Diabetes Mellitus: A Randomized Controlled Trial, Complementary Therapies in Medicine (2017)
13. Possible Potentials of Curcumin for Pregnancies Complicated by Intra-Uterine Growth Restriction: Role of Inflammation, Angiogenesis, and Oxidative Stress, Heliyon (2021)
14. Administration of Dietary Antioxidants for Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials, Complementary Therapies in Medicine (2021)
15. Beneficial Effects of Nano-Curcumin Supplement on Depression and Anxiety in Diabetic Patients With Peripheral Neuropathy: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, Phytotherapy Research (2020)
16. Therapeutic Effects of Curcumin on Sepsis and Mechanisms of Action: A Systematic Review of Preclinical Studies, Phytotherapy Research (2019)
17. A Novel Combination of Ω-3 Fatty Acids and Nano-Curcumin Modulates Interleukin-6 Gene Expression and High Sensitivity C-Reactive Protein Serum Levels in Patients With Migraine: A Randomized Clinical Trial Study, CNS and Neurological Disorders - Drug Targets (2018)
18. Mechanisms of Apoptosis Modulation by Curcumin: Implications for Cancer Therapy, Journal of Cellular Physiology (2019)
19. Effects of Folic Acid Supplementation on Inflammatory Markers: A Grade-Assessed Systematic Review and Dose–Response Meta-Analysis of Randomized Controlled Trials, Nutrients (2021)
20. Does Nano-Curcumin Supplementation Improve Hematological Indices in Critically Ill Patients With Sepsis? a Randomized Controlled Clinical Trial, Journal of Food Biochemistry (2022)