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Lipopolysaccharide Preconditioning Prevents Acceleration of Kindling Epileptogenesis Induced by Traumatic Brain Injury Publisher Pubmed



Eslami M1, 2, 3, 4 ; Sayyah M3 ; Soleimani M1 ; Alizadeh L5 ; Hadjighassem M6, 7
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Source: Journal of Neuroimmunology Published:2015


Abstract

10-20% of symptomatic epilepsies are post-traumatic. We examined effect of LPS preconditioning on epileptogenesis after controlled cortical impact (CCI). LPS (0.01, 0.1 and 0.5 mg/kg) was injected i.p. to rats 5 days before induction of CCI to parieto-temporal cortex. Kindling started 24 h after CCI by i.p. injection of 30 mg/kg of pentylenetetrazole every other day until manifestation of 3 consecutive generalized seizures. CCI injury accelerated the rate of kindled seizures acquisition. LPS (0.1 and 0.5 mg/kg) prevented the acceleration of kindling. LPS preconditioning significantly decreased IL-1β and TNF-α over-expression and the number of damaged neurons in the hippocampus of traumatic rats. © 2015 Elsevier B.V..
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