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The Function of Circular Rnas in Regulating Wnt/Β-Catenin Signaling: An Innovative Therapeutic Strategy for Breast and Gynecological Cancers Publisher Pubmed



Kahkesh S1 ; Hedayati N2 ; Rahimzadeh P3 ; Farahani N4 ; Khoozani MF5 ; Abedi M6 ; Nabavi N7 ; Naeimi B8 ; Khoshnazar SM9 ; Alimohammadi M10 ; Alaei E11 ; Mahmoodieh B12
Authors

Source: Pathology, research and practice Published:2025


Abstract

Breast cancer (BC) and gynecological malignancies, including cervical, ovarian, and uterine cancers, are significant global health challenges due to their high prevalence, complex nature, and elevated mortality rates. Dysregulation of the Wnt/β-catenin signaling pathway is a common feature in gynecological malignancies, contributing to cancer cell growth, progression, migration, and metastasis. Recent studies have highlighted the pivotal role of non-coding RNAs (ncRNAs), particularly circular RNAs (circRNAs), in modulating the Wnt/β-catenin signaling pathway. Acting as sponges for microRNAs (miRNAs), circRNAs regulate key oncogenic and tumor-suppressive processes by influencing Wnt-related components. This research explores the role of circRNAs in breast and gynecological malignancies, focusing on their regulatory effects on the Wnt/β-catenin pathway. The findings reveal that circRNAs modulate critical cellular processes such as proliferation, apoptosis, autophagy, and metastasis, with potential implications for therapeutic interventions. Targeting circRNA-mediated dysregulation of Wnt signaling could offer novel strategies for improving diagnostic precision, treatment efficacy, and survival outcomes in breast and gynecological cancers. Copyright © 2025 Elsevier GmbH. All rights reserved.
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