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Alterations of the Gut Microbiome and Metabolome Following: A Opportunity for Early Detection of Colorectal Cancer Publisher



Modarres MP1 ; Habibi MA2, 3 ; Pashaei MR4 ; Mohammadpour Y5 ; Jazi K3 ; Ahmadpour S4
Authors

Source: Current Cancer Therapy Reviews Published:2025


Abstract

Colorectal cancer (CRC) is a commonly diagnosed cancer responsible for numerous deaths worldwide. In recent decades, technological advances implicated in considering the molecular pathways underlying CRC pathogenesis. Several investigations have identified various mechanisms involved in CRC and have paved the way for new therapeutics and early diagnosis. Gut microbiome play a crucial role in intestinal inflammation and can be associated with colitis colorectal cancer. In this review, we narrated the role of the microbiome population and their metabolome profile as a new screening method for early detection of CRC. © 2025 Bentham Science Publishers.
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