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Association of Hla Class Ii Alleles With Disease Severity and Treatment Response in Iranian Patients With Myasthenia Gravis Publisher Pubmed



Sinaei F1 ; Fatehi F1 ; Oveis Gharan S1, 2 ; Ehsan S1 ; Kamali K3 ; Amirzargar A4, 5 ; Mahmoudi M6 ; Vaghefifar A1 ; Nafissi S1
Authors

Source: Journal of Neuromuscular Diseases Published:2021


Abstract

Myasthenia gravis is an autoimmune neuromuscular disease with a multifactorial etiology. A major part of the genetic susceptibility belongs to the HLA encoding genes. In this study, we investigated the role of HLA class II polymorphism in disease severity, and treatment response. In our 146 patients, 15 DRB1, 7 DQA1, and 9 DQB1 alleles, and 19 haplotypes were found. Adjusted p-values did not show any significant associations between these loci, disease severity and treatment outcome. Further studies in different populations with a larger number of patients are needed to determine the exact contribution of HLA class II alleles to MG prognosis. © 2021-IOS Press. All rights reserved.
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